ANN RHEUM DIS:心血管事件相关危险因素对类风湿关节炎的影响

2017-09-08 xiangting MedSci原创

30%的CVD事件归因于RA疾病特征。这一发现表明,RA疾病特征在减少RA患者的CVD风险方面起着重要的作用。

类风湿性关节炎(RA)患者患心血管疾病(CVD)的风险明显升高。这项研究旨在评估在一个大型国际RA患者队列中CVD风险因素,包括潜在的性别差异和RA特异性指标对CVD结果的影响。

在13个风湿病中心,收集了基线的CVD危险因素和RA特征数据。使用标准化定义收集CVD结局(心肌梗塞,心绞痛,血运重建,中风,外周血管疾病和CVD死亡)。

纳入5638名此前无CVD 的RA患者,(平均年龄55.3岁(SD:14.0),女性76%)。在中位随访5.8年(SD:4.4)间,148名男性和241名女性发生CVD事件(10年累积发生率分别为20.9%和11.1%)。男性患CVD风险因素的负担较高,包括血压、总胆固醇和吸烟率均高于女性(P均 <0.001)。在传统的CVD风险因素中,吸烟和高血压的总体和不同性别间的人口归因风险(PAR)最高,其次为总胆固醇。疾病活动评分的PAR和血清阳性的幅度与脂质的PAR相当。70%的CVD事件归因于所有CVD风险因素和RA特征的结合(分别为49%的CVD危险因素和30%的RA特征)。

在大型国际RA患者队列中,30%的CVD事件归因于RA疾病特征。这一发现表明,RA疾病特征在减少RA患者的CVD风险方面起着重要的作用。

原始出处:

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    2017-10-08 cmj8wellington
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    2017-09-10 lmm397
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    2017-09-08 lovetcm

    现在临床各科都特别关心心血管事件

    0

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