Diabetes Obes Metab：低血糖严重程度与使用胰岛素的2型糖尿病患者临床和经济结局相关！

2018-01-07 xing.T MedSci原创

由此可见，使用基础胰岛素±速效/预混胰岛素并发生严重低血糖的2型糖尿病患者活动和工作效率受损程度更大，使用的医疗资源更多，并产生较高的成本，相比于那些非严重或无低血糖患者。研究还表明还对经济和健康相关生活质量结局产生影响。减少低血糖的发生率和严重程度在HRQoL上可获得临床上有意义的改善，并且降低医疗服务利用情况和费用。

近日，代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章，研究人员旨在评估采用基础胰岛素治疗的2型糖尿病（T2D）患者报告的低血糖相关的临床和患者报告的结局、患者医疗服务利用情况和费用。

该研究为一项观察性横断面调查研究，研究人员通过使用美国国家健康调查数据纳入了采用基础胰岛素±口服降糖药物（OADs）或快速/预混胰岛素治疗的成年糖尿病患者，这些患者既往经历过低血糖。符合条件的患者被归类为无低血糖（38.7%）组，无严重低血糖组（55.1%）或严重低血糖（6.2%）组。结局包括健康相关的生活质量（HRQoL）、工作效率和活动障碍、医疗资源利用率以及直接和间接成本。研究人员采用多变量回归模型来控制患者的特征。

研究人员发现相比于那些经历非严重或无低血糖的患者，那些经历过严重低血糖的患者有着显著（P＜0.05）较低的HRQoL评分，增加的整体工作效率和活动障碍，更大的医疗资源利用率和更高的成本。无严重低血糖患者也对供应商考察次数、间接成本和生活质量会产生影响。

由此可见，使用基础胰岛素±速效/预混胰岛素并发生严重低血糖的2型糖尿病患者活动和工作效率受损程度更大，使用的医疗资源更多，并产生较高的成本，相比于那些非严重或无低血糖患者。研究还表明还对经济和健康相关生活质量结局产生影响。减少低血糖的发生率和严重程度在HRQoL上可获得临床上有意义的改善，并且降低医疗服务利用情况和费用。

原始出处：

Luigi F. Meneghini, et al. The association of hypoglycaemia severity and clinical, patient-reported and economic outcomes in US patients with type 2 diabetes using basal insulin.Diabetes Obesity & Metabolism.2017. http://onlinelibrary.wiley.com/doi/10.1111/dom.13208/full

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2018-09-01 ms5439512287675881

#BET#

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2018-06-29 guojianrong

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2018-05-29 木头人513

#Diabetes#

31 0
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2018-03-07 ms9608593228839890

#DIA#

31 0
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2018-05-19 baoya

#胰岛#

29 0
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2018-07-21 一闲

#MET#

24 0
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2018-01-09 aids213

#2型糖尿病患者#

31 0
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2018-01-09 xue8604

#糖尿病患者#

28 0
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2018-01-08 wzb521zf

一起学习学习

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Diabetes Obes Metab：低血糖严重程度与使用胰岛素的2型糖尿病患者临床和经济结局相关！

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