J Thromb Haemost:心肺健康与静脉血栓栓塞风险

2019-08-27 xing.T MedSci原创

由此可见,较高的eCRF与较低的VTE事件风险相关。该关联与体重无关,表明较高的eCRF可能会改变肥胖与VTE之间的关联。

心肺健康(CRF)是未来动脉心血管疾病和过早死亡的强有力预测因子。然而,关于CRF与发生静脉血栓栓塞(VTE)风险之间关联的数据十分有限。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在调查估计的CRF(eCRF)是否与VTE事件风险相关。 

研究人员纳入了Troms研究(2007-2008)第六次调查的参与者(n=10393),并记录了截至2016年12月31日的VTE事件。根据年龄、腰围、静息心率和自我报告体力活动的性别特异性算法估算eCRF。在Cox回归模型中计算了根据eCRF类别计算的VTE风险比(HR)和95%置信区间(CI),该模型根据年龄作为时间尺度进行性别调整。在按重量分类的分析中评估体重状态的影响。

在随访期间共发生了176起VTE事件。与eCRF<85%年龄预测的个体相比,eCRF为85-100%或>100%年龄预测的个体VTE风险分别降低46%(HR为0.54; 95%CI为0.39-0.77)和67%(HR为0.33; 95%CI为0.20-0.54)。与eCRF<85%年龄预测的超重/肥胖个体相比,eCRF≥85%的超重/肥胖患者风险降低50%(HR为0.50,95%CI为0.35-0.74),eCRF≥85%的正常体重患者风险降低55%( HR为0.45,95%CI为0.30-0.68)。

由此可见,较高的eCRF与较低的VTE事件风险相关。该关联与体重无关,表明较高的eCRF可能会改变肥胖与VTE之间的关联。 

原始出处:

Line H. Evensen.et al.Cardiorespiratory fitness and future risk of venous thromboembolism.Journal of Thrombosis and Haemostasis.2019.https://doi.org/10.1111/jth.14619

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    2019-09-05 fusion
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    2019-09-02 aids222
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    2019-09-15 xue8602
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    2019-12-15 changfy

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