Med Sci Sport Exer:不同强度水平的体力活动改变老年人炎症的研究

2018-08-04 郝丽 北体大运动处方研究中心

老年人低度慢性炎症是导致许多年龄相关疾病的原因。体内炎症标志物的不断升高与糖尿病风险有关并以代谢综合征的形式呈现,它表现为一系列的代谢失调,其中包括腹型肥胖、高血压、高脂血症等。

老年人低度慢性炎症是导致许多年龄相关疾病的原因。体内炎症标志物的不断升高与糖尿病风险有关并以代谢综合征的形式呈现,它表现为一系列的代谢失调,其中包括腹型肥胖、高血压、高脂血症等。C反应蛋白(CPR)和纤维蛋白原是用来研究系统炎症与年龄相关疾病的重要指标。CPR和纤维蛋白原与男性、女性的CVD风险有关,有些研究称这与内皮细胞紊乱有关。值得注意的CPR和纤维蛋白原与慢性病和全因死亡率的关系有性别差异。与男性相比,女性纤维蛋白原与BMI指数间的关系有2倍高。

尽管体力活动和代谢性疾病的关系已得到很好的证明,但是系统性标志物的关系最近也引发大量关注。低强度和中等强度体力活动及静坐时间与系统标志物相关。同期替代模型被用来研究体力活动与全因死亡率、血管危险因素和聚集性代谢危险的关系。

目的:

客观测量体力活动水平对老年女性验证标志物及不同水平代谢风险的影响

方法:

利用加速度计测量社区常住老年女性(n=111;年龄65-70yr)的日常静坐时间、低强度体力活动时间(LPA)、中等到较大体力活动活动时间(MVPA);收集IBD%E8%AF%8A%E6%B2%BB%E8%BF%87%E7%A8%8B%E4%B8%AD%E7%9A%84%E8%AF%84%E4%BC%B0-Part%202" target="_blank">血液指标测量炎症标志物C反应蛋白(CRP)、纤维蛋白原、脂联素。根据代谢综合征的定义确定代谢风险。利用线性回归模型进行分析。

结果:

重新分配30天的静坐时间替代低强度体力活动时间(LPA)或者中等到较大体力活动活动时间(MVPA),纤维蛋白水平降低;利用低强度体力活动时间(LPA)代替中等到较大体力活动活动时间(MVPA)相关效应却不明显。相反利用中等到较大体力活动活动时间(MVPA)代替静坐时间,相关效应却很明显,CPR水平降低,但利用低强度运动时间代替静坐时间却没有发现有明显变化。

结论:

研究显示了用各种不同类型强度的运动代替静坐时间对老年女性急性期炎症蛋白会有影响。不同体力活动对炎症标志物影响不同。用轻体力活动代替静坐时间仍然会降低CRP但纤维蛋白不会减少。体力活动会改变肝脏CRP的释放。不同强度的运动能改变老年女性系统炎症反应。

原始出处:

Nilsson A, Bergens O, Kadi F. Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels[J]. Medicine & Science in Sports & Exercise, 2018, 50(7): 1502-1507.

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    2018-08-06 186****0580(小山羊)

    学习了谢谢了

    0

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    2018-08-04 飛歌

    学习了很有用

    0

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    2018-08-04 sunfeifeiyang

    0

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