Hypertension:缓解人体膳食盐含量的新机制!

2017-10-12 MedSci MedSci原创

钠的摄入量过高会引起血压(BP)升高。有动物研究表明,膳食中盐负荷可以导致VEGF-C(血管内皮生长因子C)介导的真皮Na +积累和淋巴的生成,这些都减弱了BP的上升。近期,一项发表在杂志Hypertension上的研究旨在确定这些机制是否也存在于人类中。研究者们评估了随机予以安慰剂组(70 mmol钠/ d)和缓慢钠组(200 mmol / d)的48名健康参与者中皮肤电解质、BP和血浆VEGF

钠的摄入量过高会引起血压(BP)升高。有动物研究表明,膳食中盐负荷可以导致VEGF-C(血管内皮生长因子C)介导的真皮Na +积累和淋巴的生成,这些都减弱了BP的上升。近期,一项发表在杂志Hypertension上的研究旨在确定这些机制是否也存在于人类中。研究者们评估了随机予以安慰剂组(70 mmol钠/ d)和缓慢钠组(200 mmol / d)的48名健康参与者中皮肤电解质、BP和血浆VEGF-C,共持续7天。结果以组织湿重(mg/g)测量皮肤Na +和K +浓度,并以Na +:K +的比值表示,以校正样品水合的变异性。此项研究结果显示:与安慰剂组相比,皮肤的Na +:K +在缓慢钠相之间增加(2.91±0.08 vs. 3.12±0.09; P = 0.01)。在事后分析中,有一个性别特异性效应的建议,男性皮肤的Na +:K +显着增加(2.59±0.09 vs. 2.88±0.12;P = 0.008),而不是女性(3.23±0.10 vs. 3.36± 0.12;P = 0.31)。在钠负荷条件下,女性24 h的平均血压显着升高(93±1 vs. 91±1 mm Hg,P &

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    2017-12-27 feather89
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    2017-10-15 hanmeijinxiu

    学习了.谢谢!

    0

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    2017-10-14 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=1726794, encodeId=01c01e26794b6, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Dec 27 07:18:00 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038767, encodeId=91c22038e677e, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Aug 31 14:18:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253080, encodeId=b1a92530809a, content=学习了.谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIxvMP6OXzUiaGH5MkDQlW0hczROZxec1gZjfZ52EtN6aG9t0uDZq2A5xmf9FWMa4tZib4qoYnledFg/132, createdBy=9d6c2167401, createdName=hanmeijinxiu, createdTime=Sun Oct 15 09:01:01 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350347, encodeId=418f135034ea6, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 14 12:18:00 CST 2017, time=2017-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423676, encodeId=4dc714236e61e, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Sat Oct 14 12:18:00 CST 2017, time=2017-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501214, encodeId=f2071501214d2, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Oct 14 12:18:00 CST 2017, time=2017-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252337, encodeId=15a625233e11, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Oct 12 22:54:14 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252328, encodeId=5ff725232883, content=学习了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Thu Oct 12 22:06:03 CST 2017, time=2017-10-12, status=1, ipAttribution=)]
    2017-10-14 lingqf
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    2017-10-12 惠映实验室

    学习了.谢谢

    0

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    2017-10-12 林3301

    学习了解一下

    0

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