J Periodontol:多囊卵巢综合征患者牙龈炎症和唾液或血清粒细胞分泌酶的关系

2017-11-11 MedSci MedSci原创

本研究旨在探讨在有或没有牙龈炎的多囊卵巢综合征(PCOS)和健康组,唾液和血清中的基质金属蛋白酶-9(MMP)-9,髓过氧化物酶(MPO),中性粒细胞弹性蛋白酶(NE)和基质金属蛋白酶-9(MMP-1)/组织抑制剂(TIMP) 1的比例。

本研究旨在探讨在有或没有牙龈炎的多囊卵巢综合征(PCOS)和健康组,唾液和血清中的基质金属蛋白酶-9(MMP)-9,髓过氧化物酶(MPO),中性粒细胞弹性蛋白酶(NE)和基质金属蛋白酶-9(MMP-1)/组织抑制剂(TIMP) 1的比例。

方法:对这些生物标志物的血清和唾液水平进行评估:1)PCOS的牙周健康妇女(n = 45); 2)PCOS和牙龈炎患者(n = 35); 3)全身和牙周健康的女性(n = 25);和4)患有牙龈炎的全身健康女性(n = 20)。使用酶联免疫吸附测定来确定这些生物标记的水平,并对每名患者进行牙周评估。

结果:全身健康的牙龈炎女性患者的唾液MMP-9和NE水平以及MMP-9 / TIMP-1比值均高于PCOS的牙周健康患者(P <0.001; P <0.01; P < 0.0001)。 PCOS和牙龈炎患者血清MMP-9和MPO水平高于PCOS患者(P <0.05)。健康女性牙龈炎患者血清MMP-9水平低于全身和牙周健康妇女或PCOS的牙龈炎患者(P <0.05)。 PCOS组与临床牙周参数和血清MMP-9水平或唾液MPO,NE水平和MMP-9 / MMP-1比值呈正相关。临床牙周参数与全身健康患者血清MMP-9水平及MMP-9 / TIMP-1比值相关性均为阴性(P <0.05)。

结果发现,PCOS和牙龈炎症是相互关联的,如唾液和血清中性粒细胞酶水平。这种相互作用可能导致PCOS卵巢重塑的紊乱。

原始出处:

Aliye Akcal?, et al. Gingival Inflammation and Salivary or Serum Granulocyte-Secreted Enzymes in Patients With Polycystic Ovary Syndrome. Journal of Periodontology. 2017 November. doi: 10.1902/jop.2017.170043

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    2018-08-22 feather89
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    2018-04-10 gwc392
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    2017-11-11 lofter

    学习了感谢分享

    0

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