OCC 2017:韩雅玲院士——冠心病介入治疗新近进展

2017-05-28 MedSci MedSci原创

今天召开第11届东方心脏病学会议(OCC)上,来自沈阳军区总医院全军心血管病研究所心内科的韩雅玲院士从三个方面:心肌血运重建策略的新证据、PCI相关的药物治疗进展、新型支架研究进展,回顾了2016~2017年以来冠心病介入治疗领域的新进展。 一、 心肌血运重建策略的新证据 1.EXCEL研究选取了2905名上低中危(SYNTAX得分≤32)无保护左主干患者,最终纳入1905名患者比

今天召开第11届东方心脏病学会议(OCC)上,来自沈阳军区总医院全军心血管病研究所心内科的韩雅玲院士从三个方面:心肌血运重建策略的新证据、PCI相关的药物治疗进展、新型支架研究进展,回顾了2016~2017年以来冠心病介入治疗领域的新进展。

一、 心肌血运重建策略的新证据

1.EXCEL研究选取了2905名上低中危(SYNTAX得分≤32)无保护左主干患者,最终纳入1905名患者比较依维莫司洗脱支架-PCI(N=948)和CABG(N=957)的疗效和安全性,主要终点是3年全因死亡、心肌梗死和卒中的复合终点。治疗后1个月、6个月、1年时随访,然后每年随访一次至第5年。3年随访结果表明,PCI和CABG主要终点没有显著差别(15.4% vs. 14.7%;非劣效性P=0.018;优效性P=0.98)。


结论:采用CoCr-EES治疗SYNTAX中/低危左主干患者(SYNTAX得分≤32)与CABG相比,在3年主要终点(死亡、卒中或心梗)上无显著差异,且30天不良事件发生风险更低;

因此,PCI是治疗择期左主干病变患者的一种可接受的血运重建策略,这种治疗决策应当由心脏团队讨论后决定,并应考虑患者的个体差异。

2.NOBLE研究纳入了1201名患者,比较Biolimus可降解涂层DES-PCI和CABG用于左主干血运重建的临床结果,主要终点为5年MACCE复合终点(全因死亡、非手术相关心梗、再次血运重建和卒中)。结果表明,CABG组MACCE发生率显著低于PCI组(意向治疗分析:29% vs. 19%,P=0.0066)。

这两项研究在患者入选时间、糖尿病患者比例、显著性定义、研究主要终点的定义、入组及随访时间和使用DES的类型等方面是不同的。

3. DECISION-CTO研究共招募了834名患者,其中OMT组398例,PCI组417例,主要研究终点为包含全因死亡、心肌梗死、卒中、再次血运重建在内的主要心血管不良事件(MACE)。随访1年的数据提示,OMT组主要终点事件发生率为97.5%,而PCI组发生率97.2%;随访2年分别为93.1%和91.5%;随访3年分别为87.9%和83.3%。

结论:ITT数据集分析显示,3年随访期内包括全因死亡、心梗、脑卒中或任何再次血运重建的复合终点,OMT作为初始治疗方案不劣于PCI;

然而,在PPS数据集分析中,OMT未达到非劣效于PCI的结论;

健康相关的生活质量评价在OMT和PCI两组间相当;

OMT作为CTO病变患者的初始治疗策略是合理的。

4.EURO-CTO研究于2012-2015年纳入26个中心的407名CTO患者,以2:1随机分为PCI组和OMT组,主要有效性终点为12个月时的健康状况,主要安全性终点为3年时PCI安全性。该研究是首个以患者健康状况为研究终点,对比PCI和OMT对CTO患者疗效的随机对照试验,随访1年发现,就改善患者健康状况而言,PCI优于OMT。

随访期间,PCI组和OMT组主要心脑血管不良事件(MACCE)发生率相似(5.2% vs. 6.7%,P=0.52)。PCI组手术成功率达到86.3%,手术并发症风险低(2.9%)。SAQ评估显示,PCI组患者的心绞痛症状得到显著改善(P=0.009),健康状况的其他子量表指标也有所改善,但无统计学差异。CCS心绞痛分级量表评分同样显示,PCI组患者的心绞痛状况得到大幅改善(P<0.001)。

结论:PCI能显著改善术后12个月的生活质量和心绞痛症状,围手术期并发症低(2.9%),且1年的主要不良事件与OMT相当;

主要安全性终点需要3年的数据进行评估。

但是,目前CTO的治疗策略仍然存在争议,研究证据并不充分,无论是DECISION-CTO还是EURO-CTO虽然研究存在缺陷,但均填补了这一领域的空白,应继续开展进一步研究以解决CTO治疗的争议。

二、PCI相关的药物治疗进展

1. I LOVE IT 2研究:涂层可降解DES置入患者术后6个月DAPT安全性和有效性不劣于12个月的DAPT

I LOVE IT 2研究旨在评价新型生物可降解涂层西罗莫司DES(SES)在真实世界PCI临床实践患者中的安全性和有效性,将纳入患者按照2:1随机分为接受BP-SES(n=1829)或DP-SES(n=908)。主要终点为1年的靶病变失败(TLF))发生率,主要次级终点为6个月DAPT组及12个月DAPT组间的临床净获益(NACCE),次要终点为靶病变失败中的单项指标,确定的和极可能的支架内血栓,手术成功率,患者水平的复合终点。

2. 荟萃分析:直接PCI后持续应用高剂量比伐芦定

发表于HORIZONS-AMI、EUROMAX、BRIGHT、HEAT-PPCI及MATRIX的 5项研究(包括16294例接受直接PCI的患者),比较应用普通肝素或仅PCI术中、PCI后持续高剂量、PCI后持续低剂量应用比伐芦定4种抗凝方案的有效性和安全性。结果显示,与普通肝素相比,应用比伐芦定的患者急性支架内血栓发生风险升高2倍(RR 2.36,95% CI 1.46-3.02,p<0.001),但PCI后持续高剂量应用比伐芦定并不增加急性支架内血栓发生风险(RR 0.90,95% CI 0.32-2.54,p=0.852),而PCI后持续低剂量应用比伐芦定却无此效果。同时,比伐芦定与普通肝素相比,使主要出血风险降低47%,即使采用PCI后持续高剂量应用比伐芦定的抗凝方案,减少出血的作用依然存在(RR 0.29,95% CI 0.16-0.53,p<0.001)。

需要特别指出的是,BRIGHT研究者们所提出的PCI术后持续应用3h高剂量比伐芦定的抗栓方案,完全规避了PCI术后急性支架血栓增高的风险。因此,PCI后持续高剂量应用比伐芦定是一种安全、有效的围术期抗凝方案,既克服了急性支架内血栓增高的风险,同时也不增加出血。

三、新型支架研究进展

1. ABSORB-III研究:Absorb支架治疗稳定冠心病及ACS患者的临床安全性和有效性

ABSORB-III研究共纳入了2008名患者,按照2:1随机分组,其中ABSORB组1322名,Xience组686名。随访1年,ABSORB组99.2%(1312名)的患者完成随访,Xience组98.7%(677名)的患者完成随访。随访2年,ABSORB组98.0%(1296名)的患者完成随访,Xience组97.8%(671名)的患者完成随访。两年临床结果显示,接受AbsorbBVS的患者靶病变失败风险显著高于金属支架组(10.9% VS. 7.8%)。这一差异绝大部分来自于靶血管导致的心脏病发作,AbsorbBVS和金属支架组发生率分别为7.3%和4.9%。

结论:Absorb BVS用于稳定型冠心病和稳定的ACS患者,1~2年的安全性和有效性是可接受的,1~2年支架血栓发生率仅0.3%;

虽2年的TLF Absorb BVS略高于Xience CoCr-EES(11.0% VS. 7.9%,p=0.03),但在排除<2.25mm血管后,两者TLF差别较小(9.3% VS. 7.0%,p=0.12);

更好的选择方法和技术是否可改善患者短期结局,Absorb BVS是否可较Xience CoCr-EES患者长期结局,还需ABSORB-III/IV研究的长期数据来给出答案。

2. Absorb China研究:完全生物可降解DES的临床安全性和有效性长期持续

Absorb China研究共纳入了480名PCI患者,1:1随机分组,其中其中ABSORB组241名,Xience组239名。随访1年,98.5%的患者完成随访,ABSORB组238名患者,Xience组232名患者。随访2年,96.3%的患者完成随访,ABSORB组236名,Xience组231名患者。

两年临床结果显示,相较于Xience CoCr-EES,ABSORB BVS两年节段内主要终点事件发生率持续显示非劣效性,即Absorb BVS组PoCE(10.1% vs. 11.4%,P=0.66)、靶病变失败(4.2% vs. 4.6%,P=0.82)、靶血管失败(5.5% vs. 6.8%,P=0.57)和MACE(5.1% vs. 5.1%,P=1.00)发生风险均与Xience CoCr-EES相似,进一步证实ABSORB BVS临床安全性和有效性的长期获益优势。

结论:2年的随访期内,ABSORB BVS与XIENCE V相比具有相似的临床效果(包括靶病变失败、心性死亡、靶血管心梗、缺血驱动的靶血管血运重建、支架内血栓);

PSP原则对于ABSORB BVS的植入非常重要(充分预扩张、选择合适的支架尺寸、后扩张),规范的植入有助于获得更好的临床获益。

3. NeoVas-RCT: 全降解支架NeoVas的RCT造影随访数据证明其安全性和有效性

该研究为一前瞻性、多中心、单盲、随机对照研究,共纳入了560名患者,按照1:1随机分为NeoVas(N=280)组和CoCr-EES(N=280)组。1年临床随访结果显示,靶病变失败率NeoVas组为4.3%,CoCr-EES组为3.9%(HR[95% CI]=1.11[0.49,2.52],p=0.80)。

结论:该研究为首个对比NeoVas西罗莫司涂层BRS与Xience EES对于冠脉非复杂病变的随机对照临床研究;

NeoVas BRS与CoCr-EES相比,主要终点发生率相似(1年的晚期官腔丢失);

NeoVas BRS与CoCr-EES 1年临床重点时间发生率相似且均较低(包括靶病变失败、心性死亡、靶血管心梗、缺血驱动的靶血管血运重建、支架内血栓);

1年随访时的OCT结果显示,NeoVas BRS相比CoCr-EES 具有更优的支架覆盖、支架贴壁以及内皮愈合;

术后即刻及1年随访的FFR结果在两组相似;

正在进行更长期的5年随访。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (42)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-06-01 尹玉伟

    厉害厉害……学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 laoli

    学习了,很有收获!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-30 o9887

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 zhaojie88
  7. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 1771ae4158m

    学习一下很不错

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 o9887

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 Liufeng6206

    离我们每个人都很近!学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1819875, encodeId=936718198e5e8, content=<a href='/topic/show?id=92b410004e13' target=_blank style='color:#2F92EE;'>#韩雅玲院士#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100047, encryptionId=92b410004e13, topicName=韩雅玲院士)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Mon Jul 10 09:13:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205049, encodeId=8f8920504905, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Thu Jun 01 06:09:22 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204289, encodeId=2c60204289da, content=学习了,很有收获!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Tue May 30 07:27:47 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204219, encodeId=312820421978, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Tue May 30 06:25:50 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485612, encodeId=f715148561200, content=<a href='/topic/show?id=fbf410004545' target=_blank style='color:#2F92EE;'>#韩雅玲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100045, encryptionId=fbf410004545, topicName=韩雅玲)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5f48029777, createdName=小小小向日葵, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353051, encodeId=5445135305192, content=<a href='/topic/show?id=1d931321816' target=_blank style='color:#2F92EE;'>#OCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13218, encryptionId=1d931321816, topicName=OCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 15:13:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203949, encodeId=86b2203949b0, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Mon May 29 09:22:18 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203885, encodeId=bc9f20388596, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=527f1683990, createdName=o9887, createdTime=Mon May 29 07:39:23 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203850, encodeId=316e2038509f, content=离我们每个人都很近!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon May 29 07:19:27 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203844, encodeId=159d2038445d, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:07:50 CST 2017, time=2017-05-29, status=1, ipAttribution=)]
    2017-05-29 130****4638

    学习了谢谢分享。

    0

相关资讯

Lancet Pub Health:体重与心血管疾病共患疾病风险

体重与心血管疾病的共患疾病相关,根据研究结果要求临床医生在超重和肥胖的血管疾病患者中积极筛查糖尿病并重视糖尿病患者血管疾病的预防

NEJM: 冠状动脉血管重建术中的瞬时无波率引导法

在1年的心脏风险事件方面,iFR指导的冠状动脉血管重建术非劣于FFR法,iFR法在术后不良事件及手术时间方面更具优势

Eur Heart J:近红外光谱导出的LCBI可预测冠心病患者长期随访时不良心血管结局

近红外光谱(Near-infrared spectroscopy,NIRS)能量化冠状动脉内的胆固醇的脂质核心负荷指数(LCBI)。研究人员研究了在冠状动脉疾病(CAD)患者中长期随访心脏不良结局时,由近红外光谱导出的LCBI的预后情况。研究共纳入了2009-2013年间,在275例经冠状动脉造影确诊的急性冠脉综合征(ACS)和稳定型心绞痛患者的非梗死动脉的近红外光谱数据。通过独立的corelab

JAHA:1型纤溶酶原激活物抑制物对冠心病的因果效应!

该研究的结果表明,升高的PAI-1水平对CHD风险存在因果效应,可能是通过葡萄糖代谢功能障碍所介导。

Circulation:迄今为止大规模的冠心病「基因-吸烟」研究显示,吸烟简直就是作死

宾夕法尼亚大学的研究人员开展了一项涉及14.1万人的研究,终于找到了基因学证据来解释吸烟是如何导致冠心病的。吸烟会增加一种酶的产生,而这种酶会促进冠状动脉脂肪斑块的积聚,从而增加冠心病的患病风险[1]!

冠心病患者 可以吃点鱼油

鱼油是常见的保健品,很多出国旅游的朋友回国都喜欢带一些鱼油制剂,价格不太贵,送人还很贴心。那么,到底吃鱼油效果有多大?能不能预防心脏病?最近,美国心脏协会在国际权威杂志《循环》(Circulation)上发表的文章对这个问题给出了权威解释。对于已经得冠心病的患者来说,服用鱼油可以作为二级预防用药,对于预防心源性猝死、再发心肌梗死和脑卒中等心血管事件有好处。如果患有心力衰竭,心脏收缩功能下降(左室射