Acta Biomater:矿化胶原/Mg-Ca合金组合支架具有改善的生物相容性,可增强拔牙后的骨反应

2018-11-09 MedSci MedSci原创

矿化胶原蛋白已经在临床上用作口腔应用中的骨移植材料。我们开发了矿化胶原/Mg-Ca合金组合支架,以克服矿化胶原的机械限制。本研究讨论了体外矿化胶原/Mg-Ca合金复合支架的细胞相容性和体内拔牙后骨再生的效果。 使用自ISO 10993-5的间接增殖试验,发现矿化胶原/Mg-Ca合金组合支架除了在体外未显示对MC3T3-E1细胞的细胞毒性外,还可增强了细胞增殖和迁移。最后,在犬拔牙窝位点保存模

矿化胶原蛋白已经在临床上用作口腔应用中的骨移植材料。我们开发了矿化胶原/Mg-Ca合金组合支架,以克服矿化胶原的机械限制。本研究讨论了体外矿化胶原/Mg-Ca合金复合支架的细胞相容性和体内拔牙后骨再生的效果。

使用自ISO 10993-5的间接增殖试验,发现矿化胶原/Mg-Ca合金组合支架除了在体外未显示对MC3T3-E1细胞的细胞毒性外,还可增强了细胞增殖和迁移。最后,在犬拔牙窝位点保存模型中评估组合支架增强骨生成的能力。锥形束CT,X射线显微镜和生物力学分析显示矿化胶原/Mg-Ca合金组合支架比单独矿化胶原可更有效地减少牙槽嵴的吸收。

综上所述,该研究结果表明,联合支架可以促进骨再生,具有良好的生物相容性,为矿化胶原和镁合金的联合应用提供了新的概念。

原始出处:

Guerrero J, Pigeot S, et al., Fractionated human adipose tissue as a native biomaterial for the generation of a bone organ by endochondral ossification. Acta Biomater. 2018 Sep 1;77:142-154. doi: 10.1016/j.actbio.2018.07.004. Epub 2018 Jul 4.

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    2018-12-14 windight
  2. [GetPortalCommentsPageByObjectIdResponse(id=1849620, encodeId=56c7184962052, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Dec 14 00:28:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918386, encodeId=6cac191838640, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Nov 10 05:28:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721319, encodeId=2e871e21319a5, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Dec 19 10:28:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465406, encodeId=fa121465406e9, content=<a href='/topic/show?id=662a388823e' target=_blank style='color:#2F92EE;'>#合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38882, encryptionId=662a388823e, topicName=合金)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81df6719716, createdName=楚秀娟, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574231, encodeId=4ef215e4231b7, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586638, encodeId=33571586638ba, content=<a href='/topic/show?id=155269406ec' target=_blank style='color:#2F92EE;'>#生物相容性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69406, encryptionId=155269406ec, topicName=生物相容性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6cb17357412, createdName=bnurmamat, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352082, encodeId=87c03520821b, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Fri Nov 09 23:52:12 CST 2018, time=2018-11-09, status=1, ipAttribution=)]
    2018-11-10 sunylz
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    2018-12-19 yahu
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    2018-11-11 楚秀娟
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    2018-11-11 xre2013
  6. [GetPortalCommentsPageByObjectIdResponse(id=1849620, encodeId=56c7184962052, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Dec 14 00:28:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918386, encodeId=6cac191838640, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Nov 10 05:28:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721319, encodeId=2e871e21319a5, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Dec 19 10:28:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465406, encodeId=fa121465406e9, content=<a href='/topic/show?id=662a388823e' target=_blank style='color:#2F92EE;'>#合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38882, encryptionId=662a388823e, topicName=合金)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81df6719716, createdName=楚秀娟, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574231, encodeId=4ef215e4231b7, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586638, encodeId=33571586638ba, content=<a href='/topic/show?id=155269406ec' target=_blank style='color:#2F92EE;'>#生物相容性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69406, encryptionId=155269406ec, topicName=生物相容性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6cb17357412, createdName=bnurmamat, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352082, encodeId=87c03520821b, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Fri Nov 09 23:52:12 CST 2018, time=2018-11-09, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1849620, encodeId=56c7184962052, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Fri Dec 14 00:28:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918386, encodeId=6cac191838640, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Nov 10 05:28:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721319, encodeId=2e871e21319a5, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Wed Dec 19 10:28:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465406, encodeId=fa121465406e9, content=<a href='/topic/show?id=662a388823e' target=_blank style='color:#2F92EE;'>#合金#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38882, encryptionId=662a388823e, topicName=合金)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=81df6719716, createdName=楚秀娟, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574231, encodeId=4ef215e4231b7, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586638, encodeId=33571586638ba, content=<a href='/topic/show?id=155269406ec' target=_blank style='color:#2F92EE;'>#生物相容性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69406, encryptionId=155269406ec, topicName=生物相容性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6cb17357412, createdName=bnurmamat, createdTime=Sun Nov 11 13:28:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352082, encodeId=87c03520821b, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Fri Nov 09 23:52:12 CST 2018, time=2018-11-09, status=1, ipAttribution=)]
    2018-11-09 红色

    很好

    0