Dig Liver Dis:非肥胖的非酒精性脂肪性肝病患者患糖尿病的风险增加

2018-02-06 MedSci MedSci原创

研究结果表明,非肥胖的NAFLD患者患糖尿病的风险显著增加

非酒精性脂肪性肝病(NAFLD)与心脏代谢疾病相关。本研究旨在评NAFLD的长期肝外并发症,并在非肥胖患者中对NAFLD进行评估。

选自2000年健康体检中心的2920例参与者,对这些参与者进行随访,直到2010年12月。通过超声诊断NAFLD。根据体重指数、NAFLD和代谢综合征,对受试者进行分层。

非肥胖的NAFLD受试者和代谢不良的非肥胖者的患病率分别为14.4%和8.7%。多元统计分析中,非肥胖的NAFLD患者发生糖尿病的风险显著增加(HR 2.69, 95% CI 1.72-4.20, P<0.001),患高血压和心血管疾病的风险未见增加。代谢不良的非肥胖者患高血压(HR 2.75, 95% CI 2.02-3.74, P<0.001)、糖尿病(HR 5.72, 95% CI 3.68-8.89, P<0.001)和心血管疾病(HR 2.93, 95% CI 1.53-5.63, P=0.001)的风险均显著增高。非肥胖受试者的亚组分析显示,无代谢综合征的NAFLD患者患糖尿病风险更高(HR 3.60, 95% CI 2.03-6.39, P<0.001)。

研究结果表明,非肥胖的NAFLD患者患糖尿病的风险显著增加。

原始出处

Kim SS, Cho HJ, Kim HJ, et al. Nonalcoholic fatty liver disease as a sentinel marker for the development of diabetes mellitus in non-obese subjects. Dig Liver Dis, 2017, Dec 27. doi: 10.1016/j.dld.2017.12.018.

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