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Diabetes Care：ω-3多不饱和脂肪酸或可降低T2DM风险

2013-09-16 完美事业 dxy

ω-3多不饱和脂肪酸T2DM
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鱼类或ω-3多不饱和脂肪酸(PUFA)与2型糖尿病的关系尚不明确。鱼类中的污染物，如水银，甚至都可能会改变其中的作用。为了研究芬兰中老年男性血清中ω-3 PUFAs：二十碳五烯酸(EPA)，二十二碳五烯醇(DPA)、二十二碳六烯酸(DHA)、α-亚麻酸(ALA)及发汞与2型糖尿病发生风险的相关性，来自芬兰库奥皮奥东芬兰大学公共卫生和临床营养研究院的Virtanen等进行了一项研究，血清长链ω-3

鱼类或ω-3多不饱和脂肪酸(PUFA)与2型糖尿病的关系尚不明确。鱼类中的污染物，如水银，甚至都可能会改变其中的作用。为了研究芬兰中老年男性血清中ω-3 PUFAs：二十碳五烯酸(EPA)，二十二碳五烯醇(DPA)、二十二碳六烯酸(DHA)、α-亚麻酸(ALA)及发汞与2型糖尿病发生风险的相关性，来自芬兰库奥皮奥东芬兰大学公共卫生和临床营养研究院的Virtanen等进行了一项研究，血清长链ω-3 PUFA浓度与长期2型糖尿病风险较低有关。研究结果在线发表于2013年9月11日的美国《糖尿病治疗》(Diabetes Care)杂志上。【原文下载】

研究对象为2212名男性，来自一项前瞻性、以人口为基础的库奥皮奥缺血性心脏疾病危险因素研究，基线检查在1984-1989年进行，参与者年龄42-60岁，无2型糖尿病。血清PUFA和发汞作为暴露的生物标志物。采用4天的食物记录对膳食摄入量进行评估。2型糖尿病采用自填问卷、空腹和2h口服葡萄糖耐量试验血糖指标(基线后4年、11年和20年复查时测定)进行评价，同时也通过医院的出院登记和糖尿病药物使用报销登记的记录连接。采用Cox比例风险模型分析相关性。

结果显示，在平均随访期19.3年间，422名男性发生2型糖尿病。与血清EPA+DPA+DHA最低四分位数的男性比较，血清EPA+DPA+DHA最高四分位数的男性多变量校正的2型糖尿病风险降低33%(趋势检验P值为0.01)。未观察到2型糖尿病与血清或膳食ALA，鱼类或EPA+DHA、发汞有统计学显著性相关性。

研究表明，血清长链ω-3 PUFA浓度，是摄入鱼类的客观标志物，与长期2型糖尿病风险较低有关。

原文下载

Virtanen JK, Mursu J, Voutilainen S, Uusitupa M, Tuomainen TP.Serum Omega-3 Polyunsaturated Fatty Acids and Risk of Incident Type 2 Diabetes in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study.Diabetes Care. 2013 Sep 11.

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    2013-10-20 木头人513

    #Diabetes#

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    2014-05-11 12498ca5m92暂无昵称

    #不饱和脂肪酸#

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createdBy=65aa2977309, createdName=millore, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579940, encodeId=22eb15e994054, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2014-07-31 quxin068

    #3多不饱和脂肪酸#

    0

  4. 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    2014-08-08 wwzzly

    #饱和脂肪酸#

    0

  5. 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    2014-05-31 ms5439512287675881

    #BET#

    0

  6. 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createdBy=65aa2977309, createdName=millore, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579940, encodeId=22eb15e994054, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2014-04-01 ms9608593228839890

    #DIA#

    0

  7. 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createdBy=65aa2977309, createdName=millore, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579940, encodeId=22eb15e994054, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2013-09-30 quxin068

    #3多不饱和脂肪酸#

    0

  8. 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createdBy=65aa2977309, createdName=millore, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579940, encodeId=22eb15e994054, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2013-09-18 zll0625

    #多不饱和脂肪酸#

    0

  9. 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createdBy=65aa2977309, createdName=millore, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579940, encodeId=22eb15e994054, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Wed Sep 18 06:26:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2013-09-18 millore

    #ω-3多不饱和脂肪酸#

    0

  10. 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    2013-09-18 斯嘉莉

    #饱和脂肪#

    0

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