Eur J Prev Cardiol:改善冠心病患者的临床结局 从药物依从性入手

2017-06-22 安雅晶 石岩 环球医学

药物治疗可以缓解冠心病患者的症状,减少心绞痛的发作和心肌梗死,并降低死亡率。2017年6月,发表在《Eur J Prev Cardiol》的一项由中国科学家进行的meta分析,考察了药物依从性对冠心病的临床结局的影响。背景:国际指南建议长期使用循证药物治疗稳定性冠心病,但药物的不依从性很普遍。此meta分析的目的是系统评价药物依从性对稳定性冠心病患者临床结局的影响。

药物治疗可以缓解冠心病患者的症状,减少心绞痛的发作和心肌梗死,并降低死亡率。2017年6月,发表在《Eur J Prev Cardiol》的一项由中国科学家进行的meta分析,考察了药物依从性对冠心病的临床结局的影响。

背景:国际指南建议长期使用循证药物治疗稳定性冠心病,但药物的不依从性很普遍。此meta分析的目的是系统评价药物依从性对稳定性冠心病患者临床结局的影响。

方法:检索1960年1月~2015年12月,MEDLINE和EMBASE数据库中的论文,无语言限制。进行meta分析以考察药物依从性良好组与药物依从性不佳组之间,全因死亡率、心血管死亡率和心肌梗死/住院的风险比。研究由两名研究人员独立评价。从合格的研究中选取数据,使用R软件3.1.0版进行meta分析。

结果:分析总共纳入10项研究,共106002名冠心病患者。结果表明,对循证药物方案依从性良好,包括β-阻滞剂、血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂、抗血小板药物和他汀,与全因死亡率(风险比0.56,95% 置信区间:0.45~0.69)、心血管死亡率(风险比0.66,95%CI:0.51~0.87)和心血管住院/心肌梗死(风险比0.61,95%CI:0.45~0.82)的低风险相关。

结论:本项meta分析证实了良好的药物依从性对稳定性冠心病患者的临床结局具有显着影响。需要更多的策略和计划来改善药物依从性。

原始出处:

Du L, Cheng Z, et al. The impact of medication adherence on clinical outcomes of coronary artery disease: A meta-analysis. Eur J Prev Cardiol. 2017 Jun;24(9):962-970. doi: 10.1177/2047487317695628. 

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    2017-06-26 虈亣靌

    值得推荐一下

    0

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    2017-06-24 fyxzlh
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    2017-06-23 清风拂面

    谢谢分享,获益匪浅

    0

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    2017-06-23 jyzxjiangqin

    改善冠心病患者的临床结局。

    0

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    2017-06-22 杨利洪

    学习了分享了

    0

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