Neurology:海马和杏仁核是中枢性呼吸暂停发作的产生症状区

2017-01-15 xing.T MedSci原创

海马和杏仁核是人类边缘呼吸控制区域,并且是中枢性呼吸暂停发作的产生症状区。

中枢性呼吸暂停指没有胸腹呼吸运动时上气道无气流通过的时间大于10s,单纯的中枢性呼吸暂停的很少的,一般不超过10%,但是对于中枢性呼吸暂停发作患者长期的缺氧会导致心力衰竭,血压升高,心跳加快,甚至出现心律紊乱,心脏停止。因此,探究中枢性呼吸暂停发作的潜在发生机制尤为重要。近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在确定人类大脑中的掌管呼吸控制的边缘区域,并推而广之,来确定中枢性呼吸暂停的产生症状区。

在这项研究中,研究人员采用根据解剖结构精确放置的立体定向脑电图电极的直接刺激来对呼吸反应结果进行分析。研究人员通过脑立体定向植入的深部电极来探究中枢性呼吸暂停的产生症状区,并且前瞻性地研究了3例患者的杏仁核、海马,以及边缘位置以往的脑区(如眶额叶、颞尖和颞皮层)。

通过对不同脑区的直接刺激,研究人员发现当对参与者的杏仁核和海马头刺激时可以一致性地引起呼气相中枢性呼吸暂停,这一呼气相中枢性呼吸暂停与精确的海马局灶性癫痫发作相一致。而刺激其他研究脑区,均未出现相似的研究现象。

该研究的结果表明,海马和杏仁核是人类边缘呼吸控制区域,并且是中枢性呼吸暂停发作的产生症状区。

原始出处:


Nuria Lacuey, et al. Amygdala and hippocampus are symptomatogenic zones for central apneic seizures. Neurology. January 13, 2017.  

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    2017-10-05 yinhl1978
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    2017-01-17 paperyu
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    2017-01-16 默默道来

    每梅斯,每日学习

    0

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    2017-01-16 卡圣

    学习了新动态了

    0

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    2017-01-16 Johnson_zhangdr

    学习了,打算给同事们讲一讲

    0

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    2017-01-15 inter158

    中枢性呼吸暂停发作患者长期的缺氧会导致心力衰竭,血压升高,心跳加快,甚至出现心律紊乱,心脏停止。

    0