Hypertension:无肾病的高血压患者高蛋白摄入与死亡率降低相关

2016-07-24 phylis 译 MedSci原创

蛋白质的摄入量可能对降低血压和心血管事件有一定的好处,但它们的影响仍是有争议的。本研究的目的是测试在肾功能良好的高血压患者中,24小时尿蛋白评估蛋白质摄入量的预后价值。根据蛋白质的摄入水平,1128例高血压患者进行随访,校正的理想体重:<0.70,0.70-0.93,和大于0.93g/kg。基线特征(平均值±标准差)年龄45.1±13.2岁、收缩压/舒张压185±32/ 107±20mmHg,估计

蛋白质的摄入量可能对降低血压和心血管事件有一定的好处,但它们的影响仍是有争议的。本研究的目的是测试在肾功能良好的高血压患者中,24小时尿蛋白评估蛋白质摄入量的预后价值。

根据蛋白质的摄入水平,研究人员对1128例高血压患者进行随访,校正的理想体重:<0.70,0.70-0.93,和大于0.93g/kg。基线特征(平均值±标准差)年龄45.1±13.2岁、收缩压/舒张压185±32/ 107±20mmHg,估计肾小球滤过率82±32mL/min。

随访10年中, 289例死亡,其中202例为心血管原因。校正主要心血管危险因素,与蛋白摄入最低组相比,蛋白质摄入量第二组和第三组的患者全因死亡(HR0.71, 95% [ CI],[ 0.56-0.91 ])和心血管死亡(0.72 [ 0.54-0.96 ])风险降低,而与脑卒中死亡(0.72 [ 0.41-1.28 ])不相关。正常高蛋白摄入与某些人群良好预后相关:年轻患者、低盐饮食、无主动脉粥样硬化、或以前的心血管事件。高血压患者蛋白质摄入量>0.7g/kg理想体重,尤其是那些在低风险者,可降低其全因死亡率和心血管死亡率。

医生可能会鼓励高血压患者正常或高蛋白饮食、低盐饮食、适度饮酒、规律的身体活动。

原始出处:

Courand PY, Lesiuk C, et al. Association Between Protein Intake and Mortality in Hypertensive Patients Without Chronic Kidney Disease in the OLD-HTA Cohort. Hypertension. 2016 Jun


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    2017-01-25 feather89
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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

    0

  4. 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    2016-08-28 ylzr123

    深度好文,值得学习,赞!

    0

  6. 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    2016-08-27 ylzr123

    好文,值得学习,赞一个。

    0

  7. 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    2016-08-16 忠诚向上

    好好学习

    0

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    2016-07-26 海豹

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