JAHA:抗癫痫药物与阿尔茨海默病患者的卒中风险

2018-09-16 xing.T MedSci原创

由此可见,无论AED类型如何,服用AED都与卒中风险增加有关。该研究结果强调了AED在这个脆弱人群中应谨慎使用。

阿尔茨海默病(AD)患者比一般的老年人更容易发作癫痫发作,并且使用抗癫痫药物(AEDs)的频率更高。AED的使用与一般人群血管事件的高风险有关;然而,AD患者是否存在相同的风险并不明显。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了AD患者与使用AED相关的卒中风险。

药物使用和阿尔茨海默病(MEDALZ)队列包含了从2005年到2011年期间临床AD诊断(N=70718)的所有芬兰人。研究人员排除既往卒中的患者,对于每个服用AED的患者(n=5617),根据AD诊断时的性别、年龄和时间匹配一个未服用AED的患者,并使用Cox比例风险模型和治疗加权的逆概率进行分析。

与未服药者相比,服用AED与卒中风险增加相关(治疗加权风险比(HR)的逆概率为1.37; 95%置信区间[CI]为1.07-1.74)。在AED使用的前90天(调整HR为2.36; 95%CI为1.25-4.47)卒中风险最强。根据卒中类型,与缺血性卒中(逆概率治疗加权HR为1.34; 95%CI为1.00-1.79)和出血性卒中(逆概率治疗加权HR为1.44; 95%CI为0.86-2.43)相关。服用AED时间较长的患者卒中风险与新服用AED患者的卒中风险没有差异(调整后的HR为1.04; 95%CI为0.71-1.53)。

由此可见,无论AED类型如何,服用AED都与卒中风险增加有关。该研究结果强调了AED在这个脆弱人群中应谨慎使用。

原始出处:


Tatyana Sarycheva.et al. Antiepileptic Drug Use and the Risk of Stroke Among Community‐Dwelling People With Alzheimer Disease: A Matched Cohort Study.JAHA.2018. https://www.ahajournals.org/journal/jaha

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createdTime=Sun Sep 16 12:44:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345231, encodeId=8a8834523177, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Sun Sep 16 10:54:17 CST 2018, time=2018-09-16, status=1, ipAttribution=)]
    2018-09-18 zhaohui6731
  5. 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  6. 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createdTime=Sun Sep 16 12:44:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345231, encodeId=8a8834523177, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Sun Sep 16 10:54:17 CST 2018, time=2018-09-16, status=1, ipAttribution=)]
  7. 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  8. 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createdTime=Sun Sep 16 12:44:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345231, encodeId=8a8834523177, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Sun Sep 16 10:54:17 CST 2018, time=2018-09-16, status=1, ipAttribution=)]
    2018-09-16 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  9. 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createdTime=Sun Sep 16 12:44:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345231, encodeId=8a8834523177, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Sun Sep 16 10:54:17 CST 2018, time=2018-09-16, status=1, ipAttribution=)]
    2018-09-16 guging

    中风是俗称,应该称为缺血性卒中吧

    0

  10. 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createdTime=Sun Sep 16 12:44:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345231, encodeId=8a8834523177, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Sun Sep 16 10:54:17 CST 2018, time=2018-09-16, status=1, ipAttribution=)]
    2018-09-16 lietome2

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

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