Inflam Bowel Dis:miR-206可以作为溃疡性结肠炎对美沙拉嗪治疗反应的生物标志物

2019-01-01 MedSci MedSci原创

微小RNA(miRNA)是重要的翻译后调节因子。溃疡性结肠炎(UC)中升高的miR-206水平与抗炎性A3腺苷受体(A3AR)表达的抑制相关。然而,miR-206与UC患者组织学缓解的关系目前还不清楚。本研究将miR-206的表达水平与通过长期美沙拉嗪治疗的患者的组织学缓解进行研究分析,以确定该主要药物对UC的可能作用的模式。

背景及目的
微小RNA(miRNA)是重要的翻译后调节因子。溃疡性结肠炎(UC)中升高的miR-206水平与抗炎性A3腺苷受体(A3AR)表达的抑制相关。然而,miR-206与UC患者组织学缓解的关系目前还不清楚。本研究将miR-206的表达水平与通过长期美沙拉嗪治疗的患者的组织学缓解进行研究分析,以确定该主要药物对UC的可能作用的模式。

方法
在患者服用美沙拉嗪的不同时间点(0,4,12和24小时),通过qRT-PCR和蛋白质印迹分析,在HT29细胞系中分析miR-206及其靶A3AR的表达。在用美沙拉嗪治疗2至6年的10名UC患者中研究miR-206的表达和结肠镜活检标本的病理评分相关性。

结果
与对照组相比,在HT29结肠细胞中美沙拉嗪处理后4小时,miR-206转录物减少2.23倍(P = 0.0001)。然而,在相同细胞中,A3AR的mRNA /蛋白质水平分别增加了4倍(P = 0.04)和2倍。用4.8g美沙拉嗪治疗的患者(P = 0.002),miR-206相对表达显着下降。结肠镜活检的组织评估表明miR-206的下调与组织学改善之间存在强相关性(R = 0.9111)。

结论
美沙拉嗪的使用对上皮miRNA有影响。通过长期美沙拉嗪的治疗可以下调miR-206,同时维持组织学缓解的保护作用。因此,miR-206表达水平可以用于美沙拉嗪治疗的治疗反应的生物标志物。

原始出处:
Carlos D Minacapelli. Et al. miR-206 as a Biomarker for Response to Mesalamine Treatment in Ulcerative Colitis. Inflammatory Bowel Diseases. 2018.

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    2019-06-18 yuandd
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encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 07 12:47:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930673, encodeId=441f19306e3b4, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 10 17:47:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695055, encodeId=9d23169505517, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Aug 07 01:47:00 CST 2019, time=2019-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057644, encodeId=d434205e644b4, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Apr 23 23:47:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454844, encodeId=e82414548443b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512683, encodeId=2c15151268345, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560792, encodeId=b94b1560e9204, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=)]
    2019-06-07 hukaixun
  5. [GetPortalCommentsPageByObjectIdResponse(id=1702861, encodeId=50f51e0286150, content=<a href='/topic/show?id=ea9ae99666e' target=_blank style='color:#2F92EE;'>#美沙拉嗪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79966, encryptionId=ea9ae99666e, topicName=美沙拉嗪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf3e30418720, createdName=zhangyxzsh, createdTime=Mon Sep 23 18:47:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977436, encodeId=786e19e7436ba, content=<a href='/topic/show?id=57613630b9' target=_blank style='color:#2F92EE;'>#Bow#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3630, encryptionId=57613630b9, topicName=Bow)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 18 19:47:00 CST 2019, time=2019-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012891, encodeId=f01b201289126, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Jun 03 15:47:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841343, encodeId=9869184134316, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 07 12:47:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930673, encodeId=441f19306e3b4, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 10 17:47:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695055, encodeId=9d23169505517, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Aug 07 01:47:00 CST 2019, time=2019-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057644, encodeId=d434205e644b4, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Apr 23 23:47:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454844, encodeId=e82414548443b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512683, encodeId=2c15151268345, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560792, encodeId=b94b1560e9204, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=)]
    2019-03-10 smallant2002
  6. [GetPortalCommentsPageByObjectIdResponse(id=1702861, encodeId=50f51e0286150, content=<a href='/topic/show?id=ea9ae99666e' target=_blank style='color:#2F92EE;'>#美沙拉嗪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79966, encryptionId=ea9ae99666e, topicName=美沙拉嗪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf3e30418720, createdName=zhangyxzsh, createdTime=Mon Sep 23 18:47:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977436, encodeId=786e19e7436ba, content=<a href='/topic/show?id=57613630b9' target=_blank style='color:#2F92EE;'>#Bow#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3630, encryptionId=57613630b9, topicName=Bow)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, 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encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 07 12:47:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930673, encodeId=441f19306e3b4, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 10 17:47:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695055, encodeId=9d23169505517, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Aug 07 01:47:00 CST 2019, time=2019-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057644, encodeId=d434205e644b4, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Apr 23 23:47:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454844, encodeId=e82414548443b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512683, encodeId=2c15151268345, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560792, encodeId=b94b1560e9204, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=)]
    2019-08-07 nymo
  7. [GetPortalCommentsPageByObjectIdResponse(id=1702861, encodeId=50f51e0286150, content=<a href='/topic/show?id=ea9ae99666e' target=_blank style='color:#2F92EE;'>#美沙拉嗪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79966, encryptionId=ea9ae99666e, topicName=美沙拉嗪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf3e30418720, createdName=zhangyxzsh, createdTime=Mon Sep 23 18:47:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977436, encodeId=786e19e7436ba, content=<a href='/topic/show?id=57613630b9' target=_blank style='color:#2F92EE;'>#Bow#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3630, encryptionId=57613630b9, topicName=Bow)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, 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encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 07 12:47:00 CST 2019, time=2019-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930673, encodeId=441f19306e3b4, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun Mar 10 17:47:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695055, encodeId=9d23169505517, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Aug 07 01:47:00 CST 2019, time=2019-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057644, encodeId=d434205e644b4, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Apr 23 23:47:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454844, encodeId=e82414548443b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512683, encodeId=2c15151268345, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560792, encodeId=b94b1560e9204, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=)]
    2019-04-23 lxg951
  8. 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time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560792, encodeId=b94b1560e9204, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Thu Jan 03 10:47:00 CST 2019, time=2019-01-03, status=1, ipAttribution=)]
    2019-01-03 xiaoyeshuang
  9. 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