Neurology:左心室壁运动异常与缺血性卒中患者卒中复发有关

2017-01-13 xing.T MedSci原创

左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在观察左心室室壁运动异常对与高危的心源性栓塞疾病无关的脑卒中复发的作用。


该研究纳入了续性就诊的急性缺血性卒中患者,经胸超声心动图对脑卒中患者进行常规评价,研究的结局为任何卒中和缺血性卒中的复发时间。

研究人员共纳入了4316例急性缺血性卒中患者,430例患者有左心室壁运动异常,但无高危心源性栓子来源。患者发生任何卒中和缺血性卒中风险的中位观察时间分别为24.5个月和24.7个月。在随访期间,310例(7.2%)患者发生任何类型的卒中复发,而250例(5.8%)患者出现缺血性卒中复发。对传统的心血管风险因素、实验室结果、影像学变量和治疗的干预措施进行调整后,左心室壁运动异常与研究结局存在相关性(对于任何类型的卒中其风险比为1.707,95%可信区间为1.262–2.310;对于缺血性卒中其风险比为1.709,95%可信区间为1.222–2.390)。

此外,在将与单变量回归结果显著相关的协变量进行校正后,左心室壁运动异常仍然可以被看作是独立的危险因素(对于任何类型的卒中其风险比为1.747,95%可信区间为1.292–2.364;对于缺血性卒中其风险比为1.704,95%可信区间为1.219–2.382)。除他汀类药物治疗亚组外,其他亚组中左心室壁运动异常与研究结局之间不存在显著的相互作用。

本研究的结果表明,左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。

原始出处:

Jeong-Yoon Choi, et al. Left ventricular wall motion abnormalities are associated with stroke recurrence. Neurology.January 11, 2017.

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    2017-09-04 yinhl1978
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createdBy=8217292, createdName=yinhl1978, createdTime=Mon Sep 04 10:55:00 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720144, encodeId=bb501e20144f3, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Mar 01 08:55:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813908, encodeId=1570181390879, content=<a href='/topic/show?id=101f9416466' target=_blank style='color:#2F92EE;'>#运动异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94164, encryptionId=101f9416466, topicName=运动异常)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Wed Apr 26 00:55:00 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892820, encodeId=503d1892820b2, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Jul 23 18:55:00 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806125, encodeId=50c9180612537, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Aug 14 03:55:00 CST 2017, time=2017-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171358, encodeId=15f61e1358f2, content=很感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d32a1717978, createdName=1debbfffm06(暂无匿称), createdTime=Thu Jan 19 11:53:19 CST 2017, time=2017-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391606, encodeId=2bce13916067e, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36036, encryptionId=f8ab3603664, topicName=卒中复发)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Sun Jan 15 04:55:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413179, encodeId=7aac14131e9f6, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Sun Jan 15 04:55:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170268, encodeId=a88a1e026862, content=左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jan 14 10:36:02 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-04-26 gous
  5. 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Aug 14 03:55:00 CST 2017, time=2017-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171358, encodeId=15f61e1358f2, content=很感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d32a1717978, createdName=1debbfffm06(暂无匿称), createdTime=Thu Jan 19 11:53:19 CST 2017, time=2017-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391606, encodeId=2bce13916067e, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, 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15 04:55:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170268, encodeId=a88a1e026862, content=左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jan 14 10:36:02 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
  6. 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Aug 14 03:55:00 CST 2017, time=2017-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171358, encodeId=15f61e1358f2, content=很感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d32a1717978, createdName=1debbfffm06(暂无匿称), createdTime=Thu Jan 19 11:53:19 CST 2017, time=2017-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391606, encodeId=2bce13916067e, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, 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15 04:55:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170268, encodeId=a88a1e026862, content=左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jan 14 10:36:02 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
  7. 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topicList=[TopicDto(id=94164, encryptionId=101f9416466, topicName=运动异常)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Wed Apr 26 00:55:00 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892820, encodeId=503d1892820b2, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Jul 23 18:55:00 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806125, encodeId=50c9180612537, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Aug 14 03:55:00 CST 2017, time=2017-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171358, encodeId=15f61e1358f2, content=很感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d32a1717978, createdName=1debbfffm06(暂无匿称), createdTime=Thu Jan 19 11:53:19 CST 2017, time=2017-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391606, encodeId=2bce13916067e, content=<a href='/topic/show?id=f8ab3603664' target=_blank style='color:#2F92EE;'>#卒中复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36036, encryptionId=f8ab3603664, topicName=卒中复发)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Sun Jan 15 04:55:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413179, encodeId=7aac14131e9f6, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Sun Jan 15 04:55:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170268, encodeId=a88a1e026862, content=左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jan 14 10:36:02 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-19 1debbfffm06(暂无匿称)

    很感谢分享

    0

  8. 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  9. 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  10. 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15 04:55:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170268, encodeId=a88a1e026862, content=左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jan 14 10:36:02 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-14 ylzr123

    左心室壁运动异常,即使与高危心源性栓塞来源无关,可能是缺血性卒中患者卒中复发的独立预测因素。

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