Diabetes:研究发现缺乏维生素D与糖尿病之间的密切关系,缺乏易患糖尿病!

2017-10-24 佚名 Medicalxpress

发表在《糖尿病》杂志上的一项研究,在婴儿期和童年期获得足够的维生素D与降低儿童患1型糖尿病的基因风险的可能性有关。

发表在《糖尿病》杂志上的一项研究,在婴儿期和童年期获得足够的维生素D与降低儿童患1型糖尿病的基因风险的可能性有关。

该研究的主要作者吉尔·诺里斯和她的合着者研究了血液中维生素D水平与胰岛自身免疫性之间的关系。

免疫系统攻击胰岛细胞内产生胰岛素的胰岛细胞时,胰岛自身抗体就会出现,这是1型糖尿病的前兆。

“几年来,科学家一直在争论维他命D是否降低了胰岛自身免疫性和1型糖尿病的风险。”诺里斯博士说。

1型糖尿病是一种慢性自身免疫性疾病,每年在全球范围内增长3 - 5%。这种疾病现在是10岁以下儿童中最常见的代谢紊乱。在年幼的儿童中,新病例的数量尤其多。高纬度地区的风险似乎更大,从赤道以北更远。

维生素D代表1型糖尿病的候选保护性因素,因为它调节免疫系统和自身免疫性。此外,维生素D的地位因纬度而异。但是维生素D水平和胰岛自身免疫性之间的联系是不一致的。这可能是由于不同的研究设计,维生素D水平的人口变化,或者没有考虑到维生素D通路中暴露和潜在遗传变异的综合影响。

这项研究是由美国国立卫生研究院(National Institutes of Health)的国家糖尿病、消化和肾脏疾病研究所(National Institutes of Health)国家研究所(National Institutes of Health)的国家研究所(National Institutes of Health's National Institute of糖尿病、消化和肾脏疾病)资助的一项大型、多国家研究的研究成果,是糖尿病环境决定因素的一部分。

本研究的目的是在8,676名患有1型糖尿病风险的儿童中寻找1型糖尿病的诱因和保护性因素。

从婴儿期开始,每隔三到六个月就会抽取一个孩子的血液样本,以确定胰岛自身免疫性的存在,以及维生素D的水平。

作者对376名儿童进行了比较,其中有1041名儿童没有得到自动免疫。作者发现,在维生素D受体基因的基因变异的儿童中,婴儿和童年时期的维生素D水平较低,而那些没有发展自身免疫性的儿童则可以自动免疫。

这项研究首次表明,较高的儿童维生素D水平与降低患病风险有显着关联。

“由于这种关联并不能证明因果关系,我们希望未来的研究能够证实维生素D的干预是否有助于预防1型糖尿病,”诺里斯博士说。

原始出处:
Jill M. Norris, Hye-Seung Lee, Brittni Frederiksen,et al.Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity.Diabetes 2017 Oct; db170802. https://doi.org/10.2337/db17-0802

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