Chest:囊性纤维化患者的中枢神经功能障碍表现

2017-04-28 MedSci MedSci原创

囊性纤维化(CF)跨膜调节蛋白(CFTR)的功能障碍可以导致CF。目前,患者生存率的提高使得能够检测到越来越微妙的疾病表现。CFTR的中枢神经系统(CNS)功能障碍可能会扰乱昼夜节律,从而影响睡眠期。近期,一项发表在杂志Chest上的文章研究了成年人的睡眠,以更好地了解CFTR潜在的CNS 功能障碍。研究者们从2012年4月至2015年4月期间招募参加者,并对慕尼黑时计调查问卷(MCTQ)进行管理

囊性纤维化(CF)跨膜调节蛋白(CFTR)的功能障碍可以导致CF。目前,患者生存率的提高使得能够检测到越来越微妙的疾病表现。CFTR的中枢神经系统(CNS)功能障碍可能会扰乱昼夜节律,从而影响睡眠期。

近期,一项发表在杂志Chest上的文章研究了成年人的睡眠,以更好地了解CFTR潜在的CNS 功能障碍。

研究者们从2012年4月至2015年4月期间招募参加者,并对慕尼黑时计调查问卷(MCTQ)进行管理。研究者们比较了CF和非CF参与者之间的自由睡眠测量,并研究了与CF存活相关的预测因子。

此项研究共招募了23名女性和22名男性成年CF患者,年龄18-46岁;以及22名男性,26名女性的志愿者,年龄18-45岁。与非CF志愿者相比,CF患者具有延迟入睡(0.612小时,P = 0.015),中度睡眠(1.11小时,P <0.001)和觉醒次数(1.15小时,P <0.001)以及延长的睡眠潜伏期(7.21分,P = 0.05)和持续时间(0.489小时,P = 0.05)。

在CF患者中,每一小时的入睡延迟导致睡眠持续时间为0.29小时,而在非CF中的睡眠持续时间为0.75小时(P = 0.007);而CF患者的睡眠潜伏期延长了0.15小时,而在非CF中则为0.05小时(P = 0.035 )。在CF患者中,FEV1%先于急性肺部恶化,并且体重与所有自由睡眠测量无关。

此项研究表明:成人中的CF与睡眠期明显延迟相符,与昼夜节律相延迟一致。独立于预测生存的疾病特征表明睡眠期延迟是CNS中CFTR功能障碍的主要表现。

原始出处:
Jensen JL, Jones CR, et al. Sleep Phase Delay in Cystic Fibrosis: A Potential New Manifestation of Cystic Fibrosis Transmembrane Regulator Dysfunction. Chest. 2017 Apr 22. pii: S0012-3692(17)30739-0. doi: 10.1016/j.chest.2017.03.057.

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    2017-11-23 Smile2680
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    2018-01-12 wolongzxh
  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624203, encodeId=6626162420392, content=<a href='/topic/show?id=a9b2222e60a' target=_blank style='color:#2F92EE;'>#中枢神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22276, encryptionId=a9b2222e60a, topicName=中枢神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1fcf20658765, createdName=smlt2015, createdTime=Sun Apr 30 11:37:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192087, encodeId=6d0019208efd, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  5. 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  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624203, encodeId=6626162420392, content=<a href='/topic/show?id=a9b2222e60a' target=_blank style='color:#2F92EE;'>#中枢神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22276, encryptionId=a9b2222e60a, topicName=中枢神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1fcf20658765, createdName=smlt2015, createdTime=Sun Apr 30 11:37:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192087, encodeId=6d0019208efd, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Apr 30 09:11:31 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191602, encodeId=fb2219160262, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Apr 29 00:03:58 CST 2017, time=2017-04-29, status=1, ipAttribution=)]
    2017-04-30 清风拂面

    学习了,谢谢!

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Apr 30 09:11:31 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191602, encodeId=fb2219160262, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Apr 29 00:03:58 CST 2017, time=2017-04-29, status=1, ipAttribution=)]
    2017-04-29 天涯183

    非常好的文章,学习了,很受益

    0