BMC Gastroenterology: 睡眠障碍患者中的非酒精性脂肪肝疾病发生情况

2020-02-16 不详 MedSci原创

非酒精性脂肪肝疾病(NAFLD)是最常见的慢性肝病之一。研究表明,睡眠呼吸暂停与NAFLD相关。然而,关于睡眠障碍与NAFLD之间的关联的研究非常有限。因此,本项研究旨在对这方面进行相关研究。

背景
非酒精性脂肪肝疾病(NAFLD)是最常见的慢性肝病之一。研究表明,睡眠呼吸暂停与NAFLD相关。然而,关于睡眠障碍与NAFLD之间的关联的研究非常有限。因此,本项研究旨在对这方面进行相关研究。

方法
研究人员使用国家健康保险研究数据库收集了在2000年至2005年期间在台湾确定了被诊断患有睡眠障碍的患者,并从与比较人群相同的数据库中选择了相同数量的无睡眠障碍的患者。研究人员使用Cox比例风险模型来评估与睡眠障碍相关的NAFLD风险。

结果
本项研究共纳入33045名睡眠障碍患者。在比较人群中,NAFLD的发生率在睡眠障碍患者中为每10000人年14.0,每10000人年为6.2。与睡眠障碍相关的NAFLD调整后的危险比(AHR)为1.78(95%置信区间[95%CI]:1.46–2.16),其他独立的危险因素包括男性(AHR = 1.31,95%CI:1.12–11.54),40-59岁的年龄(AHR = 1.49,95%CI:1.21-1.82)和血脂异常(AHR = 2.51,95%CI:2.08-3.04)。在亚组分析中,有(AHR = 2.24,95%CI:1.05–4.77)和无(AHR = 1.77,95%CI:1.46–2.15)睡眠呼吸暂停的患者都有增加NAFLD的风险。

结论
睡眠障碍与NAFLD相关,即使在没有睡眠呼吸暂停的患者中也是如此。

原始出处:

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    2020-10-29 苏小雨

    学习了非常好

    0

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    2020-05-18 许安
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  5. 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  6. 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心血管(CV)疾病是非酒精性脂肪肝(NAFLD)患者死亡的首要原因,而女性可以预防心血管疾病。本项研究旨在确定女性在NAFLD中是否仍然是预防心血管疾病(心肌梗塞,心绞痛和中风)的保护因素。

J Hepatology: 在肥胖的非酒精性脂肪肝患者中发生肝外癌症的风险比较高

癌症是非酒精性脂肪性肝病(NAFLD)患者死亡的主要原因,而肥胖是癌症的危险因素;但是,NAFLD在这种关联中的作用尚不清楚。因此,本项研究对此进行了相关研究。