J Periodontal Res: 血清NT-proBNP水平与牙周炎的关系

2018-07-22 MedSci MedSci原创

N-末端脑利尿钠肽（NT-proBNP）在炎症期间表达并被认为是心血管疾病（CVD）的生物标志物。在过去十年中，有证据表明牙周炎与心血管疾病有关。然而，NT-proBNP在牙周病中的潜在作用鲜为人知。本研究的目的是检查牙周组织中NT-proBNP的水平是否增加，以及是否与牙周炎的严重程度有关。

N-末端脑利尿钠肽（NT-proBNP）在炎症期间表达并被认为是心血管疾病（CVD）的生物标志物。在过去十年中，有证据表明牙周炎与心血管疾病有关。然而，NT-proBNP在牙周病中的潜在作用鲜为人知。本研究的目的是检查牙周组织中NT-proBNP的水平是否增加，以及是否与牙周炎的严重程度有关。

进行病例对照研究，从40名牙周炎患者和40名非牙周炎患者中收集血清样本。在所有受试者中进行全口牙周检查。还记录了人口统计学信息，某些疾病的临床参数和病史。在实验室中进行血清NT-proBNP和高灵敏度C-反应蛋白浓度的测定。

结果：与对照组相比，牙周炎患者血清中NT-proBNP水平显着升高（87.9 pg / mL vs 29.9 pg / mL，P <.0001）。此外，随着牙周病的发展，NT-proBNP水平升高。多变量回归分析显示，牙周炎症面积（牙周炎症和疾病活动的量度）是唯一与血清中NT-proBNP浓度升高显着相关的牙周参数（R2 = .777，P <.0001）。

在牙周炎样本中观察到血清NT-proBNP水平升高。此外，牙周破坏程度越大，血清中NT-proBNP的水平越高。

原始出处：

Y. Leira， et al. Brain natriuretic peptide serum levels in periodontitis. Journal of Periodontal Research. 2018 August. doi： 10.1111/jre.12546

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2018-10-31 feather89

#PE#

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2018-07-24 huiwelcome

#BNP#

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2018-07-24 mjldent

#NT-proBNP#

31 0
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2018-07-24 仁医06

#牙周#

30 0
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2018-07-24 sunylz

#PRO#

30 0
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2018-07-24 jihuaijun1112

学习学习学习

59 0
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2018-07-23 liumin1987

BNP与牙周炎有关。学习了。

44 0
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2018-07-23 飛歌

厉害了我的妹

46 0
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2018-07-22 天地飞扬

了解一下，谢谢分享！

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