BMC Nephrol:牙周炎可增加肾病的死亡率

2017-08-19 MedSci MedSci原创

牙周炎常见于慢性肾脏疾病(CKD)者中,但是目前仍不确定牙周病是否是CKD患者过早死亡的独立危险因素。目前各种降低CKD患者死亡率的干预措施并不尽人意,因此亟需制定新的指标。因此,本次荟萃分析旨在评估CKD患者牙周病与死亡率之间的关系。研究人员检索了PubMed、Embase、Web of Science、Scopus以及近期相关会议的摘要。计算总体和亚组分析的相对危险度(RRs)及95%可信区间

牙周炎常见于慢性肾脏疾病(CKD)者中,但是目前仍不确定牙周病是否是CKD患者过早死亡的独立危险因素。目前各种降低CKD患者死亡率的干预措施并不尽人意,因此亟需制定新的指标。因此,本次荟萃分析旨在评估CKD患者牙周病与死亡率之间的关系。

研究人员检索了PubMed、Embase、Web of Science、Scopus以及近期相关会议的摘要。计算总体和亚组分析的相对危险度(RRs)及95%可信区间。使用卡方检验探讨统计学异质性,并使用I2统计量进行量化。

结果共纳入了八个队列研究,包括5477名CKD患者。汇总数据表明,牙周病与CKD患者的全因原因死亡有关(RR,1.254;95% CI 1.046 - 1.503;P = 0.005),异质性中等,I2 = 52.2%。然而,并未发现牙周病和心血管死亡率之间存在相关性(RR,1.30,95% CI,0.82 - 2.06;P=0.259)。此外,统计异质性明显(I2 = 72.5%,P = 0.012)。校正混杂因素后,亚组之间死亡率的关联相似,如CKD的不同阶段。特异性全因死亡、敏感性和累积分析都表明该研究结果是可靠的。至于心血管疾病的死亡率,与牙周病的关联并不显著。

总之,该研究表明牙周病与CKD患者全因死亡的风险增加有关。然而,没有充分的证据表明牙周病也会增加心血管死亡的风险。

原始出处:

Jian Zhang, Hong Jiang, et al., Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies. BMC Nephrol. 2017; 18: 269. Published online 2017 Aug 16. doi: 10.1186/s12882-017-0680-9.

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    2017-08-20 戒馋,懒,贪

    有点意思,学习了

    0

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    2017-08-20 三生有幸9135

    学习一下谢谢分享

    0

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    2017-08-20 184****9840

    学习了谢谢分享

    0

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    2017-08-19 xiaotaiyang1

    看看了解一下,谢谢分享

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