Stroke:如何管理围手术期发生的大动脉闭塞性卒中?

2017-12-12 杨中华 脑血管病及重症文献导读

围手术期卒中(Perioperative strokes,POS)定义为手术期间或手术后30天内发生的急性缺血性卒中,是一种手术后少见并发症,通常见于神经系统、心脏或血管外科手术。即使采用最佳内科治疗方案,其死亡率仍高达25%,以及高致残率,特别与非POS相比。


围手术期卒中(Perioperative strokes,POS)定义为手术期间或手术后30天内发生的急性缺血性卒中,是一种手术后少见并发症,通常见于神经系统、心脏或血管外科手术。即使采用最佳内科治疗方案,其死亡率仍高达25%,以及高致残率,特别与非POS相比。

最近,机械性血栓切除术已经成了大动脉闭塞性急性缺血性卒中的标准治疗方案。鉴于近期手术是静脉溶栓的禁忌症,因此机械血栓切除术可能是大动脉闭塞性POS的最佳治疗方案。

2017年11月来自法国的Kévin Premat等在Stroke上发表了他们的研究结果,目的在于比较POS和非POS采取机械性血栓切除术的疗效。

从2010年到2017年共25例POS患者采取了机械性血栓切除术,根据闭塞部位、年龄和NIHSS评分共配对了50例连续非POS患者(对照组)。

POS组和非POS组平均年龄分别为68.3和67.2岁(P = 0.7),平均NIHSS分别为20和19(P = 0.79)。POS组和非POS组3个月时mRS 0-2分分别为33.3%和56.5%(P = 0.055),成功再通率(mTICI >=2b)分别为76%和86%(P = 0.22),三个月死亡率分别为33.3%和4.2%(P = 0.002)。从症状发作到再灌注的时间分别为4.9h和5.2h。

最终作者认为大动脉闭塞性POS的再灌注成功率令人满意,安全性较好。不过,POS者良好预后比例更低,可能和较高的死亡率有关。

原始出处:

Premat K,et al. Mechanical Thrombectomy in Perioperative Strokes: A Case-Control Study.Stroke. 2017 Nov;48(11):3149-3151. doi: 10.1161/STROKEAHA.117.018033. Epub 2017 Oct 10.

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    2017-12-13 1e0f8808m18(暂无匿称)

    围手术期卒中.应重视.

    0

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    2017-12-12 三生有幸9135

    学习一下谢谢分享

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    2017-12-12 Y—xianghai

    学习了新知识

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    2017-12-12 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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