J Rheumatol:类风湿性关节炎、结缔组织病和血管炎的眼部表现

2020-05-08 xiangting MedSci原创

约五分之一的类风湿性关节炎患者存在眼部受累,四分之一至三分之一的结缔组织病和血管炎患者有眼部受累(干燥综合征除外,90%)。

类风湿性关节炎和其他风湿性疾病可伴有眼部表现。这项研究目的是通过荟萃分析和文献综述来确定类风湿性关节炎和其他结缔组织病眼部受累的患病率和类型。

使用Medline、Web of Science和Cochrane数据库对2019年1月7日前发表的文献进行系统检索。检索了类风湿性关节炎、系统性红斑狼疮、抗磷脂综合征、皮肌炎、多发性肌炎、系统性硬化症、干燥综合征、未分化的结缔组织病、巨细胞动脉炎、肉芽肿性多发性血管炎(GPA;原名韦格纳肉芽肿)、系统性血管炎和结节病中结膜炎、干燥性角结膜炎、干眼症、葡萄膜炎、眼出血、视神经炎、乳头水肿、眼眶疾病、视网膜动脉/静脉闭塞、黄斑水肿、视网膜炎、脉络膜视网膜炎、巩膜炎、虹膜睫状体炎、脉络膜出血、失明和一过性黑矇等疾病的患病率。

共找到3394项研究,纳入65项。类风湿性关节炎眼部受累的患病率为18%,系统性红斑狼疮为31%,抗磷脂综合征为35%,巨细胞动脉炎为27%,GPA为26%,结节病为27%。最常见的表现是眼部干燥(干燥性角结膜炎),在干燥综合征中患病率高达90%。前葡萄膜炎和后葡萄膜炎是结节病最常见的OC,分别为16%[3-28]和6%[3-9]。

约五分之一的类风湿性关节炎患者存在眼部受累,四分之一至三分之一的结缔组织病和血管炎患者有眼部受累(干燥综合征除外,90%)。

原始出处:

Matthew A. Turk. Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis. J Rheumatol. 01 May 2020.

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    2020-06-01 huiwelcome
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    2020-05-10 lmm397
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