Photodiagnosis Photodyn Ther:抗生素联合光动力疗法治疗侵袭性牙周炎的效果

2018-09-23 MedSci MedSci原创

本研究旨在评估克拉霉素与抗菌光动力疗法(aPDT)联合治疗广泛性侵袭性牙周炎的局部效果。 研究样本包括多个象限中单根牙齿上的72个牙周袋,探诊深度和临床附着水平≥5mm,探诊出血。牙周袋随机分为四组(每组n = 18):安慰剂组(UPD组),全身性克拉霉素(UPD + CLM组),aDDT(UPD + aPDT组)或全身性克拉霉素和aDDT组(UPD + CLM + aPDT组),均接受洁治

本研究旨在评估克拉霉素与抗菌光动力疗法(aPDT)联合治疗广泛性侵袭性牙周炎的局部效果。

研究样本包括多个象限中单根牙齿上的72个牙周袋,探诊深度和临床附着水平≥5mm,探诊出血。牙周袋随机分为四组(每组n = 18):安慰剂组(UPD组),全身性克拉霉素(UPD + CLM组),aDDT(UPD + aPDT组)或全身性克拉霉素和aDDT组(UPD + CLM + aPDT组),均接受洁治术。治疗前(基线)和术后3个月和6个月进行测量。评估以下参数:菌斑指数,探诊出血,探诊深度,牙龈退缩和临床附着水平。在统计分析中使用5%的显著性水平。

结果显示,在3个月时,相对于UPD组,UPD + aPDT,UPD + CLM和UPD + CLM + aPDT组均显示出减少的探测深度(p <0.05)。然而,在6个月时,抗生素组(UPD + CLM和UPD + CLM + aPDT)的平均探诊深度的降低大于UPD组和UPD + aPDT组(p <0.05)。临床附着水平方面,相对于UPD和UPD + PDT组,UPD + CLM + aPDT组明显增加(p <0.05)。

综上所述,该研究结果表明,联合克拉霉素使用时,洁治术的临床效果较aPDT更好。然而,aPDT和克拉霉素的联合应用并未带来额外的益处。

原始出处:

Bechara Andere NMR, Dos Santos NCC, et al., Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial. Photodiagnosis Photodyn Ther. 2018 Sep 15. pii: S1572-1000(18)30188-1. doi: 10.1016/j.pdpdt.2018.09.002. 

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    2019-04-06 liuxiaona
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time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346371, encodeId=e9cf3463e1a8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 24 07:35:00 CST 2018, time=2018-09-24, status=1, ipAttribution=)]
    2018-09-29 Jackie Li

    学习

    0

  5. 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time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346371, encodeId=e9cf3463e1a8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 24 07:35:00 CST 2018, time=2018-09-24, status=1, ipAttribution=)]
    2018-09-25 sunyl07
  6. 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  8. 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time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346371, encodeId=e9cf3463e1a8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 24 07:35:00 CST 2018, time=2018-09-24, status=1, ipAttribution=)]
    2018-09-24 liumin1987

    嗯嗯,学习了。

    0

  10. 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time=2018-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346371, encodeId=e9cf3463e1a8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 24 07:35:00 CST 2018, time=2018-09-24, status=1, ipAttribution=)]
    2018-09-24 明月清辉

    谢谢分享,学习了

    0