以衰老细胞为靶标的纳米载体药物递送系统

2018-08-06 MedSci MedSci原创

以衰老细胞为靶标的纳米载体药物递送系统正在成为国际医学研究的热点。受损细胞-通常称为僵尸细胞-不能发挥其正常作用,但仍然存活。靶向此类细胞是一项关键挑战,因为它们会干扰组织的功能并导致与衰老相关的持续性恶化。西班牙的细胞可塑性和疾病实验室的科学家Manuel Serrano博士开发了专门针对衰老细胞的药物传递系统。

以衰老细胞为靶标的纳米载体药物递送系统正在成为国际医学研究的热点。受损细胞-通常称为僵尸细胞-不能发挥其正常作用,但仍然存活。靶向此类细胞是一项关键挑战,因为它们会干扰组织的功能并导致与衰老相关的持续性恶化。西班牙的细胞可塑性和疾病实验室的科学家Manuel Serrano博士开发了专门针对衰老细胞的药物传递系统。

这项最新研究已经发表于《EMBO分》之上,该研究提出了一种最新的药物传递系统,该系统对含有衰老细胞的组织具有特异的选择性。Serrano博士及其同事与瓦伦西亚政治大学RamónMartínez-Máñez领导的研究小组合作,证明了该系统在体外细胞和小鼠模型中对肺纤维化和癌症的疗效。这两种疾病的特征在于存在受损细胞。这些模型显示衰老细胞比其他细胞更有效地吸收载体,并且载体一旦进入细胞内,载体的外壳就会降解以释放药物。综上所述,加载具有细胞毒性化合物的纳米载体能够杀死衰老细胞,并能改善患有肺纤维化或癌症的小鼠的健康情况。


原始出处:

https://www.europeanpharmaceuticalreview.com/news/77776/senescent-cells/

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    2019-05-14 mei539
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    2018-08-09 sillywu

    几年前纳米药物投递机器人就已经很火了呀

    0

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    2018-08-07 liumin1987

    纳米技术,学习了。

    0

  6. 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    2018-08-07 kafei

    学习了谢谢

    0

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GetPortalCommentsPageByObjectIdResponse(id=336918, encodeId=c7cc336918e3, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Aug 06 23:16:43 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-07 太阳系小猪

    很酷的研究,后期是否可以用于预防衰老

    0

  8. 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    2018-08-06 清风拂面

    谢谢分享学习

    0

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    2018-08-06 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦哦

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