JAMA Neurol:非酒精性脂肪肝加速脑老化进程

2017-11-21 zhangfan MedSci原创

研究认为非酒精性脂肪性肝病与脑总体积缩小有关,且该相关性独立于内脏脂肪与心血管代谢危险因素,这一现象表明肝脂肪变性与脑老化之间存在的联系

非酒精性脂肪性肝病(NAFLD)是一种常见病症,通常无症状,与代谢综合征糖尿病、颈动脉粥样硬化和内皮功能障碍有关,而这些疾病又与脑损伤和认知障碍密切相关。近日研究人员考察了非酒精性脂肪性肝病人的脑结构变化。

Framingham研究中,766名志愿者参与,患者无酗酒、中风和痴呆史,通过腹部多层螺旋计算机断层扫描评估非酒精性脂肪性肝病症状。研究的主要终点是非酒精性脂肪性肝病与脑磁共振结构变化。脑MRI检查包括全脑体积、海马和白质高信号以及隐蔽性脑梗塞。

766名参与者,女性410人,平均年龄67岁,137人(17.9%)存在NAFLD。多因素调整后,非酒精性脂肪性肝病与脑总体积缩小有关(β[SE], -0.26 [0.11]; P=0.02)。非酒精性脂肪性肝病阳性对于所有参试者相当于4.2年的脑老化,对于60岁以上人群相当于7.3年的脑老化。非酒精性脂肪性肝病与海马和白质高信号或隐蔽性脑梗塞不相关。

研究认为非酒精性脂肪性肝病与脑总体积缩小有关,且该相关性独立于内脏脂肪与心血管代谢危险因素,这一现象表明肝脂肪变性与脑老化之间存在的联系。

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    2017-11-27 yinhl1978
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    2017-11-21 惠映实验室

    学习了.谢谢.

    0

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    2017-11-21 执着追梦

    学习.谢谢分享

    0

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Am J Gastroenterol:地中海饮食、非酒精性脂肪肝与胰岛素抵抗

研究认为,坚持地中海饮食模式可降低非酒精性脂肪肝患病率,对于NAFLD患者,高地中海饮食依从性可降低胰岛素抵抗

BMC Complement Altern Med:牛磺酸联合茶多酚改善非酒精性脂肪肝炎

非酒精性脂肪性肝炎(NASH)是非酒精性脂肪肝疾病(NAFLD)的进展表现,目前尚无安全有效的药物治疗手段,传统中医药是否能发挥一定的作用呢?近日,来自我国中国人民解放军总医院的一项研究提示:牛磺酸联合茶多酚(TPs)可一定程度上缓解NASH,或可作为治疗NASH患者的一种新型有效药物。

东大学子发现去铁制剂治疗非酒精性脂肪肝新机制

铁是细胞生长所需的基本元素,但是铁过量也会导致机体的损害,而铁离子螯合剂可以显着影响细胞内外的铁水平,在临床上多用于治疗人体铁元素过载带来的各种疾病。日前,东大学子通过实验研究发现,铁螯合剂去铁敏(DFO)对非酒精性脂肪肝具有明确的减轻作用,在减少动物血脂等方面意义重大,为临床治疗非酒精性脂肪肝等脂类代谢紊乱相关疾病提供了理论依据。

盘点:近期非酒精性脂肪肝重要研究进展一览

脂肪肝,是指由于各种原因引起的肝细胞内脂肪堆积过多的病变。脂肪性肝病正严重威胁国人的健康,成为仅次于病毒性肝炎的第二大肝病。脂肪肝是一种常见的临床现象,而非一种独立的疾病。其临床表现轻者无症状,重者病情凶猛。非酒精性脂肪性肝病是指除外酒精和其他明确的损肝因素所致的肝细胞内脂肪过度沉积为主要特征的临床病理综合征,与胰岛素抵抗和遗传易感性密切相关的获得性代谢应激性肝损伤。这里梅斯小编整理了近期关于非酒

Diabetologia:使用HOMA-IR诊断非酒精性脂肪肝

最近欧洲的非酒精性脂肪性肝指南(NAFLD)要求设定HOMA-IR的参考值。近日,国际杂志 《Diabetologia》上在线发表一项关于基于人群和实验室间的使用HOMA-IR诊断非酒精性脂肪肝的研究。在本研究中,研究人员旨在确定:(1)两个基于群体的队列中正常HOMA-IR的上限;(2)对应于NAFLD的HOMA-IR;(3)rs738409的性别和PNPLA3基因型对HOMA-IR的影响; 和

JCEM:非酒精性脂肪肝发病机制研究—— III型纤连蛋白质组件包含蛋白5 rs3480 A>G多态性、鸢尾素和肝纤维化之间的关系

关于非酒精性脂肪肝(NAFLD)发病机制,之前有研究报道关于鸢尾素的作用,它是由 III型纤连蛋白质组件包含蛋白5(FNDC5)基因编码的新型肌肉激素。近日,在医学权威杂志JCO上面发表了一篇研究文章,研究人员对非酒精性脂肪肝(NASH)患者检测了FNDC5变异、肝表达和肝损伤的循环鸢尾素,以F2-F4纤维化作为主要结果。研究人员还研究了在实验模型中鸢尾素是否调节肝细胞脂肪积累和星状细胞活化。