Eur Heart J:老年人停用他汀,心血管事件风险明显增加

2019-08-07 xujing 中国循环杂志

欧洲心脏病学杂志发表的一项基于人群的队列研究显示,服用他汀类药物治疗的老年患者,如果停药,则心血管事件风险显着增加。

欧洲心脏病学杂志发表的一项基于人群的队列研究显示,服用他汀类药物治疗的老年患者,如果停药,则心血管事件风险显着增加。

研究者分析了在过去两年中服用他汀类药物的75岁的心血管健康状况良好的老年人,排除了所有被诊断出患有心血管疾病的人,以及正在服用其他药物治疗或预防心脏或血管问题的人。

研究人员对12万名受试者进行了最多4年的随访(平均2.4年)。在此期间,14.3%至少连续三个月停止服用他汀类药物,4.5%因心血管疾病入院。

停止他汀类药物治疗者的心血管事件风险增加33%。冠状动脉事件的风险增加46%,血管疾病(如中风)风险增加了26%。

据研究者估计,与继续服用他汀类药物的人相比,那些在75岁时停止服用他汀类药物的人每100人在4年内会发生额外的2.5例心血管事件。

研究指出,在他们研究的人群中,他汀类药物的停用率(14.3%)出乎意料地低,这可能是因为该研究只纳入了过去两年连续服用他汀类药物的人群。

人们中断他汀类药物治疗有很多原因。在这项研究中,研究者确定了一些原因,除了副作用是停止服用他汀的原因,其他健康问题、癌症、住院或日常护理的变化(如入住疗养院、进食问题)也会导致停药。

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    2019-08-09 zhaojie88
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    2019-08-09 slcumt

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