Stroke:收缩压与血管性痴呆的风险呈正相关

2016-07-24 phylis 译 MedSci原创

背景:血管性痴呆是第二大常见痴呆形式,但血压(BP)和血管性痴呆发生的风险特定年龄的相关性的可靠证据是有限的,一些研究报告在年龄较大的负面联想。方法:从电子初级保健健康档案(英国临床实践研究数据库)中识别无已知的心血管疾病和老年痴呆症428万人。研究者将BP和诊断血管性痴呆的时间联系起来。研究者在短暂性脑缺血发作和卒中(牛津血管研究)中进行潜在性的记录,探讨血压和老年痴呆症之间的关联。结果:随访时

背景:血管性痴呆是第二大常见痴呆形式,但血压(BP)和血管性痴呆发生的风险特定年龄的相关性的可靠证据是有限的,一些研究报告在年龄较大的负面联想。

方:从电子初级保健健康档案(英国临床实践研究数据库)中识别无已知的心血管疾病和老年痴呆症428万人。研究者将BP和诊断血管性痴呆的时间联系起来。研究者在短暂性脑缺血发作和卒中(牛津血管研究)中进行潜在性的记录,探讨血压和老年痴呆症之间的关联。

结果:随访时间的中位数为7年,排除第一个4年的随访,在初级保健队列中11114个初表现为血管性痴呆症。

通常随着年龄的增长,收缩压和血管性痴呆的风险的相关性降低(收缩压每升高20 mm Hg,30-50岁:HR 1.62;95%CI,1.13-2.35;51-70岁(1.26、1.18-1.35);71~90岁(0.97、0.92-1.03))。在校正卒中和短暂性脑缺血发作后,常用的收缩对血管性痴呆有预测价值。在以人群为基础的队列中,以前的收缩压可预测5年内痴呆的风险,没有证据表明在老年人存在负相关。

结论:血压与血管性痴呆的风险呈正相关,不论是否发生短暂性脑缺血发作或卒中。以前的报告,并未证实老年期会呈负相关。

原始出处:

Selwaness M, Bos D, et al. Carotid Atherosclerotic Plaque Characteristics on Magnetic Resonance Imaging Relate With History of Stroke and Coronary Heart Disease. Stroke. 2016 Jun


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    2016-09-12 zutt
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    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

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    2016-10-09 1e0ece0dm09(暂无匿称)

    谢谢谢谢指点

    0

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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