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CLIN CHEM：在功能性相关冠状动脉疾病检测中使用统一和性别特异性方法直接比较心肌肌钙蛋白T和I

2018-11-02 MedSci MedSci原创

心肌肌钙蛋白T心肌肌钙蛋白I
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本研究旨在直接比较高灵敏度心肌肌钙蛋白I (hs-cTnI)和高灵敏度心肌肌钙蛋白T (hs-cTnT)在功能相关冠心病(fCAD)检测中的应用。 研究对象包括有fCAD疑似临床症状，但除冠状动脉疾病外无结构性心脏病的连续转诊的患者。基于休息/应力心肌灌注单光子发射计算机断层扫描/计算机断层扫描和冠状动脉造影检测fCAD。以盲法测定hs-cTnI和hs-cTnT浓度。使用ROC曲线下面积(A

本研究旨在直接比较高灵敏度心肌肌钙蛋白I (hs-cTnI)和高灵敏度心肌肌钙蛋白T (hs-cTnT)在功能相关冠心病(fCAD)检测中的应用。

研究对象包括有fCAD疑似临床症状，但除冠状动脉疾病外无结构性心脏病的连续转诊的患者。基于休息/应力心肌灌注单光子发射计算机断层扫描/计算机断层扫描和冠状动脉造影检测fCAD。以盲法测定hs-cTnI和hs-cTnT浓度。使用ROC曲线下面积(AUC)对诊断准确性进行量化，并分别对所有患者的统一使用和性别特异性使用进行评估。预后终点为2年内主要不良心脏事件(MACEs;心血管死亡或心肌梗死)。对于预后表现，研究人员使用了与Akaike信息标准(AIC)的多变量模型比较。

研究结果显示，在2062例患者中有613例(29.7%)检测到fCAD, 其中664例女性中有112例(16.9%)，1398例男性中有501例(35.8%) fCAD患者。hs-cTnI和hs-cTnT在对所有患者进行统一使用评估时具有类似的诊断准确性(AUC, 0.68 vs 0.66;P = 0.107)，女性(AUC, 0.68 vs 0.63;P = 0.068)和男性(AUC, 0.65 vs 0.64;P = 0.475)。然而，女性需要较低的标准来达到高灵敏度，而男性则需要较高的标准来达到高特异性。hs-cTnI和hs-cTnT在2年内与狼疮性肾炎密切且独立相关(P < 0.001)， AIC具有相似的预后准确性。

研究表明，hs-cTnI和hs-cTnT具有中等和类似的诊断准确性。两种肌钙蛋白的预后效用相当。

原始出处：

Deborah Mueller, Christian Puelacher, Ursina Honegger, Direct Comparison of Cardiac Troponin T and I Using a Uniform and a Sex-Specific Approach in the Detection of Functionally Relevant Coronary Artery Disease

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    2019-01-27 jinweidong

    #特异性#

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    2019-01-04 feather78

    #疾病检测#

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    2019-09-12 xlxchina

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    2018-11-04 howi

    #冠状动脉疾病#

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    2018-11-04 wrj0124

    #心肌肌钙蛋白#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1899249, encodeId=e7ea1899249e5, content=<a href='/topic/show?id=6f746e94170' target=_blank style='color:#2F92EE;'>#特异性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67941, encryptionId=6f746e94170, topicName=特异性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc7a157, createdName=jinweidong, createdTime=Sun Jan 27 03:54:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799433, encodeId=3d101e99433bb, content=<a href='/topic/show?id=eb5ae068750' target=_blank style='color:#2F92EE;'>#疾病检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70687, encryptionId=eb5ae068750, topicName=疾病检测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3679417, createdName=feather78, createdTime=Fri Jan 04 02:54:00 CST 2019, time=2019-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915491, encodeId=82961915491a8, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Sep 12 20:54:00 CST 2019, time=2019-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252923, encodeId=b7a112529234a, content=<a href='/topic/show?id=463230886b8' target=_blank style='color:#2F92EE;'>#冠状动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30886, encryptionId=463230886b8, topicName=冠状动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Nov 04 01:54:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490318, encodeId=ea331490318d5, content=<a href='/topic/show?id=72a651322e0' target=_blank style='color:#2F92EE;'>#心肌肌钙蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51322, encryptionId=72a651322e0, topicName=心肌肌钙蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1de58724110, createdName=wrj0124, createdTime=Sun Nov 04 01:54:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569123, encodeId=5347156912345, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Sun Nov 04 01:54:00 CST 2018, time=2018-11-04, status=1, ipAttribution=)]
    2018-11-04 huangdf

    #肌钙蛋白T#

    0