Clinica Chimica Acta:中国人群中与血心肌肌钙蛋白I浓度相关的生物学和时间因素

2019-09-16 Gladiator MedSci原创

心肌肌钙蛋白是诊断急性心肌梗死的基础生物标志物。

心肌肌钙蛋白是诊断急性心肌梗死的基础生物标志物。这项研究的目的是评估生物和时间因素与较大数量中国门诊患者的血浆心肌肌钙蛋白IcTnI)浓度之间的关系,并探讨哪个因素(性别,年龄,采血时间和季节年)对血浆cTnI水平的影响最大。

201211日至2018920日,从实验室信息系统下载门诊cTnI结果分析数据。所有cTnI测量均采用Siemens Dimension EXL全自动化学发光免疫分析仪进行。采用统计方法严格排除异常值。共有86,381名门诊病人参与了这项研究。

研究显示,在60岁以上的个体中,cTnI水平随着年龄的增长在男性和女性中逐渐增加。 cTnI80岁以上的个体中达到最高水平(男性为0.030μg/ L,男性为0.027μg/ L)。在70岁以上的个体中,男性的cTnI水平显著高于女性(P <.05)。 cTnI浓度在具有不同采血时间的个体之间变化。在男性和女性中,cTnI浓度在05:00达到最大值(分别为0.030μg/ L0.026μg/ L),并在20:00再次达到峰值(分别为0.029μg/ L0.023μg/ L)。此外,一年中四季的cTnI水平存在明显差异(P <.05)。在冬季,cTnI水平通常高于春季。线性回归分析显示,年龄≥80”因子对cTnI水平的影响最大。

研究结果表明,血浆cTnI水平受性别、年龄、采血时间和季节的影响较为显著。因此,为了避免错误地将cTnI值识别为异常,应该建立一个cTnI参考区间,同时还需考虑到个体的性别和年龄、采血时间和季节。

原始出处:

Dandan LiDanying WangData mining: Biological and temporal factors associated with blood cardiac troponin I concentration in a Chinese population

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