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Chest：使用CT量化淋巴管肌瘤病的进展和治疗反应

2019-01-19 xiangting MedSci原创

淋巴管肌瘤病CT西罗莫司
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囊肿评分增加与囊肿附近纹理分解增多有关。西罗莫司治疗改善了囊肿周围的肺纹理并稳定了囊肿评分。

在淋巴管肌瘤病（LAM）中，平滑肌样LAM细胞的肺浸润导致囊性破坏和肺功能下降，可通过西罗莫司治疗达到稳定。LAM肺病部分通过高分辨率计算机断层扫描进行随访。为了从这些扫描中获得更多信息，研究人员通过分析图像"纹理"量化肺实质的变化。

通过计算机辅助系统分析像素的分布和强度来量化26个纹理特性。进行横断面和纵向研究以检查纹理特性、囊肿评分（囊肿占肺的百分比）、FEV1和DLCO之间的关系，并确定西罗莫司治疗的效果。

横断面研究中，18个纹理特性与囊肿评分呈显著正相关。西罗莫司治疗后，18个纹理特性中的13个和囊肿评分的变化率有显著差异，并且11个纹理特性能显著预测FEV1和DLCO。

囊肿评分增加与囊肿附近纹理分解增多有关。西罗莫司治疗改善了囊肿周围的肺纹理并稳定了囊肿评分。11个纹理特性与FEV1、DLCO、囊肿评分和西罗莫司治疗反应相关。纹理分析在评估LAM的严重性和治疗反应方面是有价值的。

原始出处：

Vissaagan Gopalakrishnan. Use of Computed Tomography to Quantify Progression and Response to Treatment in LAM. Chest. 17 January 2019.

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    2019-04-27 xiangyuzhou971

    #EST#

    0

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    2019-12-25 d830381

    #淋巴管肌瘤病#

    0

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    2019-04-16 Smile2680

    #Chest#

    0

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    2019-12-16 12498d2fm51(暂无昵称)

    #肌瘤病#

    0

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    2019-01-21 amyloid

    #淋巴管#

    0

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    2019-01-19 lietome15

    好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！

    0

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