NEJM:C-反应蛋白监控与COPD患者抗生素用量

2019-07-11 MedSci MedSci原创

研究认为,C-反应蛋白监控可显著减少慢性阻塞性肺疾病急性加重期患者护不必要的抗生素使用

C-反应蛋白(CRP)监控有望减少慢性阻塞性肺疾病(COPD)急性加重期患者护不必要的抗生素使用。

近日研究人员开展一项多中心、开放标签、随机对照试验,患者随机接受CRP监控护理或常规护理。研究的主要终点为4周内抗生素使用情况以及COPD相关健康状态。

653名患者参与研究,CRP组报告的抗生素使用率更低(57 vs 77.4%)。CRP组2周临床COPD问卷得分优于对照组。CRP组初次会诊中抗生素处方率显著低于对照组(47.7 vs 69.7%,OR=0.31),4周随访处方率依然较低(59.1 vs 79.7%,OR=0.30)。

研究认为,C-反应蛋白监控可显著减少慢性阻塞性肺疾病急性加重期患者护不必要的抗生素使用。

原始出处:

Christopher C. Butler et al. C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbation. N Engl J Med, July 11, 2019

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    2019-07-16 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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    2019-07-13 gous
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    2019-07-11 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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