Diabetes Care:发现糖尿病患者患痴呆、认知减退的重要风险因素

2017-05-22 浮生若梦 来宝网

根据5月12日发表在《糖尿病护理》上的最新研究,糖尿病患者的血糖峰值水平与认知衰退和痴呆有关。



根据5月12日发表在《糖尿病护理》上的最新研究,糖尿病患者的血糖峰值水平与认知衰退和痴呆有关。

糖化血红蛋白(HbAlc)是反应血糖水平一个重要指标,它与患痴呆和认知功能的损伤有关。然而血糖变异性和葡萄糖偏差在这种联系中所起到的作用还不明确。来自巴尔的摩约翰霍普金斯大学彭博公共卫生学院的Andreea M. Rawlings及其同事在近13,000名参与了动脉粥样硬化社区风险研究的人群中,考察了血糖峰值与中年人患痴呆风险和20多岁年轻人的认知衰退之间的相关性。通过1,5脱水葡萄糖(1,5-AG)来反应血糖峰值水平,临界值被设定为10μg/mL并考察HbAlc临床类型。认知功能通过3次神经心理学的测试来评价,使用Cox和线性混合效应模型通过Z比分进行统计分析。

研究人员发现有1,105名参与者发生了痴呆,发病的中位值为21年。1,5-AG每下降5 μg/mL与糖尿病患者的痴呆风险增加有关(风险比,1.16;P=0.032)。与那些没有血糖峰值的人相比,20年多年来认知下降在患糖尿病且糖化血红蛋白(HbAlc)<7%的参与者中,Z比分有0.19的下降(P=0.162)。在患糖尿病且糖化血红蛋白≥7%的参与者中,Z比分有0.38的下降(P< 0.001)。无糖尿病的人群中,血糖峰值与痴呆风险无显着关联性。

研究作者写道:“在患糖尿病的参与者中,血糖峰值是认知减退和痴呆的一个风险因素。靶向血糖峰值,除平均血糖外,可能是一个预防痴呆的重要途径。”

原始出处:

Andreea M. Rawlings, A. Richey Sharrett, et al. Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline. Diabetes Care 2017 Apr; dc162203. https://doi.org/10.2337/dc16-2203.

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    2017-05-26 惠映实验室

    疾病之间互相关联的内在机制,需要我们去探讨。

    0

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