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Materials：3D-HA/PDLLA复合材料作为颌面外科再生生物材料的可行性

2018-11-02 MedSci MedSci原创

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本研究评估了未煅烧和未煅烧的羟基磷灰石（u-HA）和聚d-l-丙交酯（PDLLA）（3D-HA / PDLLA）的新型三维（3D）多孔复合材料在颌面外科骨再生生物材料中的可行性，侧重于体外和体内的细胞活动和骨传导性。在体外研究中，我们使用3D细胞培养评估了3D-HA/PDLLA生物材料中前成骨细胞（MC3T3-E1细胞）的增殖和向内生长，结果表明生物活性增殖增强。在3D-HA/PDLLA上成骨分化

本研究评估了未煅烧和未煅烧的羟基磷灰石（u-HA）和聚d-l-丙交酯（PDLLA）（3D-HA / PDLLA）的新型三维（3D）多孔复合材料在颌面外科骨再生生物材料中的可行性，侧重于体外和体内的细胞活动和骨传导性。

在体外研究中，我们使用3D细胞培养评估了3D-HA/PDLLA生物材料中前成骨细胞（MC3T3-E1细胞）的增殖和向内生长，结果表明生物活性增殖增强。在3D-HA/PDLLA上成骨分化这些细胞后，成骨标记基因runt相关转录因子-2（Runx2）和Sp7（Osterix）的表达上调。对于体内研究，我们评估了在临界下颌骨缺损的大鼠中3D-HA / PDLLA生物材料与常规骨替代物β-磷酸三钙（β-TCP）相比的效果。结果显示，通过诱导高的骨传导性以及更高的β-TCP水平，3D-HA/PDLLA生物材料的植入导致骨再生增强。

因此，我们的研究表明，新型复合材料3D-HA/PDLLA是一种优良的生物活性/生物可吸收生物材料，可用作体外和体内细胞支架，并可用于骨再生治疗，如颌面部骨缺损不规则的患者。

原始出处：

Bai Y, Kanno T, et al., Feasibility of a Three-Dimensional Porous Uncalcined and Unsintered Hydroxyapatite/poly-d/l-lactide Composite as a Regenerative Biomaterial in Maxillofacial Surgery. Materials (Basel). 2018 Oct 20;11(10). pii: E2047. doi: 10.3390/ma11102047.

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    2019-03-05 ms4964546379600229

    #复合材料#

    0

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    2019-03-22 循证小兵

    #可行性#

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    2019-07-20 1249857fm32暂无昵称

    #生物材#

    0

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    2018-11-04 ms9833124466084992

    #3D#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2054525, encodeId=ded720545259d, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Tue Mar 05 07:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022932, encodeId=8a992022932b7, content=<a href='/topic/show?id=db3b3852004' target=_blank style='color:#2F92EE;'>#可行性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38520, encryptionId=db3b3852004, topicName=可行性)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Fri Mar 22 14:16:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076928, encodeId=c50520e6928d8, content=<a href='/topic/show?id=dc626935e20' target=_blank style='color:#2F92EE;'>#生物材#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69357, encryptionId=dc626935e20, topicName=生物材)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Sat Jul 20 16:16:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336080, encodeId=16f81336080e8, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Nov 04 06:16:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502996, encodeId=de7b150299697, content=<a href='/topic/show?id=129069358ec' target=_blank style='color:#2F92EE;'>#生物材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69358, encryptionId=129069358ec, topicName=生物材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89399597484, createdName=dongjia2013, createdTime=Sun Nov 04 06:16:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351279, encodeId=cc2c3512e970, content=希望能治愈患者, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri Nov 02 15:54:33 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
    2018-11-04 dongjia2013

    #生物材料#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2054525, encodeId=ded720545259d, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Tue Mar 05 07:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022932, encodeId=8a992022932b7, content=<a href='/topic/show?id=db3b3852004' target=_blank style='color:#2F92EE;'>#可行性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38520, encryptionId=db3b3852004, topicName=可行性)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Fri Mar 22 14:16:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076928, encodeId=c50520e6928d8, content=<a href='/topic/show?id=dc626935e20' target=_blank style='color:#2F92EE;'>#生物材#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69357, encryptionId=dc626935e20, topicName=生物材)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Sat Jul 20 16:16:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336080, encodeId=16f81336080e8, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Sun Nov 04 06:16:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502996, encodeId=de7b150299697, content=<a href='/topic/show?id=129069358ec' target=_blank style='color:#2F92EE;'>#生物材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69358, encryptionId=129069358ec, topicName=生物材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89399597484, createdName=dongjia2013, createdTime=Sun Nov 04 06:16:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351279, encodeId=cc2c3512e970, content=希望能治愈患者, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Fri Nov 02 15:54:33 CST 2018, time=2018-11-02, status=1, ipAttribution=)]
    2018-11-02 flysky120

    希望能治愈患者

    0