Heart:瓣膜面积和过高估计的主动脉瓣狭窄风险

2019-02-17 xing.T 网络

由此可见,连续方程推导的AVA正常值小于先前的参考值。在没有该疾病的患者中可以发现低于中度或重度AS的AVA临界值。流量校正指数可能会高估低压力梯度的AS患者,特别是在存在明确的危险因素的情况下。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,该研究旨在获得大群体中主动脉瓣膜面积(AVA)的参考值,并在关注流量校正的严重程度指标时推断过高主动脉瓣狭窄(AS)的风险。

研究人员前瞻性地测量了在大型转诊心脏成像实验室中进行1年的所有连续超声心动图的AS指数,并特别地分析了AS患者和非AS患者的AVA、AVA指数和速度比(Vratio)的分布,后者定义为瓣膜流出阻塞(Vmax≥2.5m/ s)和瓣膜退变的形态学改变共存。

研究人员分析了16156项研究超声心动图检查的结果,其中14669项研究未显示瓣膜阻塞(峰值射流速度<2.5 m/s)。在后一组中,在8190个研究中正常瓣膜的AVA为2.6±0.7 cm2,在6479个有主动脉硬化(AScl)的研究中为2.2±0.7cm2。在AScl和AS患者的研究中,AVA值、指数AVA和速度比之间存在相对较大的重叠。在0.5%的正常瓣膜研究和1.8%的AScl研究中AVA≤1.0cm2。这些研究中AVA≤1.5cm2的比例分别为3.1%和9.3%。在没有阻塞的患者中0.1%的个体发现Vratio≤0.25。无梗阻患者AVA的危险因素为AScl、女性、体表面积小、射血分数低和二尖瓣关闭不全。

由此可见,连续方程推导的AVA正常值小于先前的参考值。在没有该疾病的患者中可以发现低于中度或重度AS的AVA临界值。流量校正指数可能会高估低压力梯度的AS患者,特别是在存在明确的危险因素的情况下。

原始出处:

Ana González-Mansilla.et al.Valve area and the risk of overestimating aortic stenosis.Heart.2019.http://dx.doi.org/10.1136/heartjnl-2018-314482

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    2019-02-19 zhaojie88
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