Plos Med:无精神病史的女性患产后抑郁症的风险、治疗持续时间和复发的概率。

2017-09-29 qinqiyun MedSci原创

大概5%-15%的女性会患有产后抑郁症(PPD),其中很多都是首次患精神疾病。现有研究对产后情感障碍(AD)的发病率、治疗持续时间,以及在既往无精神病史的全国范围的女性队列中产后AD和其他情感发作的概率进行评估。

大概5%-15%的女性会患有产后抑郁症(PPD),其中很多都是首次患精神疾病。现有研究对产后情感障碍(AD)的发病率、治疗持续时间,以及在既往无精神病史的全国范围的女性队列中产后AD和其他情感发作的概率进行评估。

研究人员从丹麦国家注册处获取相关信息,建立研究队列,由457 317例1996年1月1日-2013年12月31日期间初次分娩、且既往无精神病院接触或服用过抗抑郁症药物的女性组成(共有789 068个新生儿)。随访时间:1996年1月1日-2014年12月31日。产后AD的定义:产后6个月使用抗抑郁症药物和(或)因为PPD到医院就诊。主要评估指标是患产后AD的风险、治疗持续时间和复发风险。

共发现4550例(0.6%)产后情感障碍发作。对治疗持续时间进行分析显示初次发作的首次治疗1年后,有27.9%的女性仍在接受治疗;4年后,仍有5.4%。第一次分娩后到PPD医院就诊过和应用过抗抑郁药物的女性,产后AD复发的风险分别是55.4/每100人年和35.0/每人年。无产后AD病史的女性第二次分娩时患产后AD的概率是1.2/每100人年。根据分娩年份和母亲年龄校准后,初产后因PPD到医院就诊和使用抗抑郁药物的女性,第二次分娩后复发产后情感障碍的概率分别是无产后AD史的女性第二次分娩后患病的概率的46.4倍(95% CI 31.5-68.4)和26.9倍(95% CI 21.9-33.2)。

在本研究中,既往无精神病史的女性分娩后有0.6%的比例发生产后情感障碍。观察的发作特点是治疗持续时间较短,而后期AD或复发产后AD的概率明显较高。初产后因PPD到医院就诊的女性复发产后AD的风险明显高于初产后服用抗抑郁药物的女性。本研究结果强调了针对特定弱势群体(如PPD为其首发精神疾病的女性)的措施的必要性。

原始出处:

Marie-Louise H.Rasmussen,et al.Risk,treatment duration,and recurrence risk of postpartum affective disorder in women with no prior psychiatric history:A population-based cohort study.Plos Med.September 26,2017.https://doi.org/10.1371/journal.pmed.1002392

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1331406, encodeId=1efb1331406cd, content=<a href='/topic/show?id=fc09244566d' target=_blank style='color:#2F92EE;'>#产后抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24456, encryptionId=fc09244566d, topicName=产后抑郁)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fa8I6JticHgohY5FSGE98I1F4gpCjrpl2nbN6jZJY6JEqAjUibjItOA9AsgbBwTuBzAPbU5Tl8DxfemWUFFzBOYw/132, createdBy=24c12500054, createdName=ms2186806800017884, createdTime=Sun Oct 01 11:18:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503635, encodeId=19761503635e0, content=<a href='/topic/show?id=4f215634296' target=_blank style='color:#2F92EE;'>#持续时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56342, encryptionId=4f215634296, topicName=持续时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13e29684821, createdName=zhwj, createdTime=Sun Oct 01 11:18:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608075, encodeId=5ee016080e584, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Oct 01 11:18:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249206, encodeId=b46a249206aa, content=需要通过长期随访吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/03/4d0fbed0ef4c156dae0e75d85c337b77.jpg, createdBy=074d2111966, createdName=138****9420, createdTime=Sat Sep 30 23:26:07 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249083, encodeId=a06224908312, content=有好还是没有好, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Sep 30 10:30:48 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248869, encodeId=6b3b24886987, content=属于观察性队列研究咯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba591726358, createdName=欣怡b88dc255, createdTime=Fri Sep 29 20:25:38 CST 2017, time=2017-09-29, status=1, ipAttribution=)]
    2017-10-01 zhwj
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    2017-09-30 138****9420

    需要通过长期随访吧

    0

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    2017-09-30 sunfeifeiyang

    有好还是没有好

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1331406, encodeId=1efb1331406cd, content=<a href='/topic/show?id=fc09244566d' target=_blank style='color:#2F92EE;'>#产后抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24456, encryptionId=fc09244566d, topicName=产后抑郁)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fa8I6JticHgohY5FSGE98I1F4gpCjrpl2nbN6jZJY6JEqAjUibjItOA9AsgbBwTuBzAPbU5Tl8DxfemWUFFzBOYw/132, createdBy=24c12500054, createdName=ms2186806800017884, createdTime=Sun Oct 01 11:18:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503635, encodeId=19761503635e0, content=<a href='/topic/show?id=4f215634296' target=_blank style='color:#2F92EE;'>#持续时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56342, encryptionId=4f215634296, topicName=持续时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13e29684821, createdName=zhwj, createdTime=Sun Oct 01 11:18:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608075, encodeId=5ee016080e584, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Oct 01 11:18:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249206, encodeId=b46a249206aa, content=需要通过长期随访吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/03/4d0fbed0ef4c156dae0e75d85c337b77.jpg, createdBy=074d2111966, createdName=138****9420, createdTime=Sat Sep 30 23:26:07 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249083, encodeId=a06224908312, content=有好还是没有好, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Sep 30 10:30:48 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248869, encodeId=6b3b24886987, content=属于观察性队列研究咯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba591726358, createdName=欣怡b88dc255, createdTime=Fri Sep 29 20:25:38 CST 2017, time=2017-09-29, status=1, ipAttribution=)]
    2017-09-29 欣怡b88dc255

    属于观察性队列研究咯

    0

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