Dig Dis Sci: 益生菌和合生元在非酒精性脂肪性肝病患者中的疗效

2019-07-06 不详 MedSci原创

流行病学证据表明,非酒精性脂肪性肝病(NAFLD)是世界范围内的主要慢性肝病。然而,一些研究表明益生菌和合生元补充剂能够减轻肝病患者的肝脏损伤。因此,本项研究旨在探明二者的关系。

背景和目的
流行病学证据表明,非酒精性脂肪性肝病(NAFLD)是世界范围内的主要慢性肝病。然而,一些研究表明益生菌和合生元补充剂能够减轻肝病患者的肝脏损伤。因此,本项研究旨在探明二者的关系。

方法
研究人员系统地搜索了PubMed,Cochrane和Embase数据库,将收集到的所有文献按照Cochrane Risk of Bias Tool评估研究质量。

结果
本项研究共纳入15项随机对照试验,涉及782例NAFLD患者。益生菌和合生元补充剂可显着改善肝脏脂肪变性,丙氨酸氨基转移酶,天冬氨酸氨基转移酶,甘油三酯,总胆固醇,高密度脂蛋白,低密度脂蛋白(P<0.05)。但补充不能改善体重指数(P= 0.99),腰围和空腹血糖(P = 0.39)。

结论
本项Meta分析证明益生菌和合生元补充剂对NAFLD患者的肝脂肪变性,肝酶,脂质谱和肝硬度有益。

原始出处:

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    2019-07-06 百草

    666

    0

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    2019-07-06 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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