J Virol:中国和美国的科学家联合开发出制备登革热候选疫苗毒株的方法

2018-10-30 Etrgh 病毒学界

目前,该病毒还没有有效的商品化疫苗来预防。近日,来自武汉病毒研究所的科学家和美国的科学家合作,开发出了一种新的制备登革热病毒疫苗毒株的方法

登革热病毒(DENV)目前流行性最广的通过蚊虫传播的病毒。登革热病毒感染后可导致患者高热,头痛,肌肉、骨关节剧烈酸痛、部分患者出现皮疹、出血倾向、淋巴结肿大。该病毒主要在热带和亚热带地区流行,我国广东、香港、澳门等地是登革热流行区。目前,该病毒还没有有效的商品化疫苗来预防。近日,来自武汉病毒研究所的科学家和美国的科学家合作,开发出了一种新的制备登革热病毒疫苗毒株的方法,该研究成果目前已发表至《Journal of Virology》杂志,题为“Using a Virion Assembly-Defective Dengue Virus as a Vaccine Approach”。

研究人员已改造后的DENV毒株为新疫苗开发平台,通过使用反向互补补充方法,将DENV野毒株的非结构蛋白2A(NS2A)整合进候选疫苗株内,拯救出弱感染力的DENV毒株-PIV NS2A。对PIV NS2A进行培养发现,其细胞感染率能达到107 IFU/ml,通过免疫小鼠发现,PIV NS2A能够刺激机体T细胞免疫反应及产生高效价的中和抗体,抵抗DENV野毒株的感染。


该研究平台的构建,将为后续DENV疫苗的开发及其他病毒候选疫苗株的构建奠定了基础。

原始出处:Shan C, Xie X, Zou J, et al. Using a virion assembly-defective dengue virus as a vaccine approach. J Virol. 2018 Aug 15.

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    2018-11-04 吴教授

    学习了,学习了,学习了

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