AP&T: 原发性硬化性胆管炎患者粪便微生物组改变与是否换结肠炎无关

2019-09-07 不详 MedSci原创

原发性硬化性胆管炎(PSC)患者粪便微生物群会出现明显改变,由于区域因素可能影响微生物群落,因此不清楚PSC的微生物特征是否存在于不同的地理区域特征,本项研究旨在确定PSC的微生物特征。

背景
原发性硬化性胆管炎(PSC)患者粪便微生物群会出现明显改变,由于区域因素可能影响微生物群落,因此不清楚PSC的微生物特征是否存在于不同的地理区域特征,本项研究旨在确定PSC的微生物特征。

方法
本项研究共纳入388名个体,137名患有PSC(n = 75有结肠炎),118名患有溃疡性结肠炎(UC)和133名健康对照。研究人员通过16S rRNA基因测序(V1-V2)分析粪便微生物组,然后对单个分类群的相对丰度的差异进行荟萃分析。

结果
PSC患者和对照之间的微生物群组成(β多样性)不同(P  <0.001)。在两个地理群组中区分PSC患者与对照组的随机森林的平均面积为0.88。与健康对照相比,PSC中发现了许多新的微生物群改变,例如Proteobacteria和耐受胆汁的Parabacteroides属的增加。相关结肠炎仅对微生物群组成具有轻微影响。

结论
PSC患者中的微生物群改变是由疾病本身而不是环境因素影响的。

原始出处:

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    2019-09-09 一个字-牛

    学习了谢谢分享

    0

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    2019-09-09 Homburg
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