BMC Complement Altern Med:牛磺酸联合茶多酚改善非酒精性脂肪肝炎

2017-09-17 佚名 国际肝病网

非酒精性脂肪性肝炎(NASH)是非酒精性脂肪肝疾病(NAFLD)的进展表现,目前尚无安全有效的药物治疗手段,传统中医药是否能发挥一定的作用呢?近日,来自我国中国人民解放军总医院的一项研究提示:牛磺酸联合茶多酚(TPs)可一定程度上缓解NASH,或可作为治疗NASH患者的一种新型有效药物。


非酒精性脂肪性肝炎(NASH)是非酒精性脂肪肝疾病(NAFLD)的进展表现,目前尚无安全有效的药物治疗手段,传统中医药是否能发挥一定的作用呢?近日,来自我国中国人民解放军总医院的一项研究提示:牛磺酸联合茶多酚(TPs)可一定程度上缓解NASH,或可作为治疗NASH患者的一种新型有效药物。
 
研究者将大鼠分配至正常组、高脂肪饮食诱导模型组和治疗组(包括牛磺酸、TPs,或牛磺酸+TPs治疗8周)。12周后,获得所有大鼠(处死后)的血清转氨酶、脂质和脂多糖水平,及肝脏氧化应激水平,并评估其组织学变化,旨在探讨牛磺酸、TPs或二者联合对NASH大鼠的作用。
 
结果,在NASH大鼠中,肝细胞损伤、脂代谢紊乱、氧化应激和脂多糖水平升高均得到证实。牛磺酸的治疗可以缓解肝细胞损伤和氧化应激。TPs治疗改善了脂质代谢,增加了肝脏的抗氧化活性。牛磺酸+TPs治疗对肝细胞损伤、脂代谢紊乱和氧化应激的疗效优于单纯牛磺酸治疗和TPs治疗。牛磺酸、TPs和二者联合治疗都降低了NASH大鼠的血清脂多糖水平,但是联合方案的效果显著优于单纯牛磺酸或单纯TPs治疗。
 
研究者认为:牛磺酸联合TPs治疗可以通过减轻肝细胞损伤、减少氧化应激,以及改善脂质代谢和肠道菌群紊乱,达到部分缓解NASH的效果。牛磺酸和TPs结合可以作为治疗NASH患者的一种新的有效药物。
 
原文链接:Zhu W, Chen S, Chen R, et al. Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats. BMC Complement Altern Med. 2017 Sep 8.

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    2018-01-27 zsyan
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    2017-11-12 xuyong536
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href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Jan 12 18:14:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676351, encodeId=e62616e63515b, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Sun Oct 01 01:14:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673329, encodeId=80b816e3329ff, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sat Jun 02 16:14:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246062, encodeId=c235246062a9, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 20 19:30:50 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402326, encodeId=e32b14023261f, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Tue Sep 19 04:14:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2018-08-01 w363522449
  5. 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createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 20 19:30:50 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402326, encodeId=e32b14023261f, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Tue Sep 19 04:14:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673329, encodeId=80b816e3329ff, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sat Jun 02 16:14:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246062, encodeId=c235246062a9, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 20 19:30:50 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402326, encodeId=e32b14023261f, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Tue Sep 19 04:14:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2018-01-12 shizhenshan
  7. 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createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 20 19:30:50 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402326, encodeId=e32b14023261f, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Tue Sep 19 04:14:00 CST 2017, time=2017-09-19, status=1, ipAttribution=)]
    2017-09-20 虈亣靌

    学习一下很不错

    0

  10. 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    2017-09-19 hbwxf

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