吡啶斯的明逆转了肉毒杆菌毒素治疗的儿科并发症

2018-01-30 MedSci MedSci原创

在一份来自南卡罗来纳医科大学(MUSC)医生的报告中得知,医生第一次使用吡啶斯的明来治疗儿童使用肉毒杆菌毒素治疗后的并发症。在这项研究中,医生使用吡啶斯的明来治疗一名经肉毒杆菌毒素治疗后患儿的并发症和另一例远端肌肉延迟并发症的患儿。在这两种情况下,医生都认识到大剂量使用吡啶斯的明可以防止早期并发症的发生。

在一份来自南卡罗来纳医科大学(MUSC)医生的报告中得知,医生第一次使用吡啶斯的明来治疗儿童使用肉毒杆菌毒素治疗后的并发症。在这项研究中,医生使用吡啶斯的明来治疗一名经肉毒杆菌毒素治疗后患儿的并发症和另一例远端肌肉延迟并发症的患儿。在这两种情况下,医生都认识到大剂量使用吡啶斯的明可以防止早期并发症的发生。

当肉毒杆菌毒素被注射到肌肉中时,它有时会向神经传导,并导致近端或远端肌肉的意外麻痹。 在这些情况下,吡啶斯的明可以通过促使肌肉收缩来逆转瘫痪。

吡啶斯的明为一种胆碱酯酶抑制剂,机理与新斯的明相似,但吡啶斯的明维持时间较久,且副作用较少,主用于重症肌无力、手术后腹气胀与尿潴留。

肉毒杆菌毒素的解毒剂很难迅速获得,且需要数天的时间才能起效,而吡啶斯的明能在数小时内缓解症状。早期治疗对于控制肉毒杆菌毒素治疗导致的并发症是至关重要的,因为这些并发症可能会导致吞咽困难或呼吸困难。

原始出处:

https://www.europeanpharmaceuticalreview.com/news/72237/pyridostigmine-botulinum-toxin-therapy/

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    2019-01-25 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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    2018-03-05 丁鹏鹏
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