Clinical Gastroenterology Hepatology:炎症性肠病增加了2型糖尿病的发病风险

2020-04-06 MedSci原创 MedSci原创

肠道也是调节体内葡萄糖的稳态的重要器官,但尚不清楚慢性肠道炎症是否会影响2型糖尿病的风险。因此,在本项研究中研究人员调查了炎症性肠病(IBD)患者的2型糖尿病的长期风险。

背景与目标:肠道也是调节体内葡萄糖的稳态的重要器官,但尚不清楚慢性肠道炎症是否会影响2型糖尿病的风险。因此,在本项研究中研究人员调查了炎症性肠病(IBD)患者的2型糖尿病的长期风险。

方法:研究人员从丹麦全国范围内的6028844人的队列研究中比较了诊断为IBD(克罗恩病[CD]或溃疡性结肠炎UC]与普通人群的数据以研究发生2型糖尿病的风险。风险以具有95%CI的标准化发生率(SIR)表示。

结果:在736072人年的随访期间,3436例IBD患者发展为2型糖尿病,而对照组为2224人(SIR,1.54; 95%CI,1.49–1.60)。UC患者(SIR,1.54; 95%CI,1.48-1.60),CD患者(SIR,1.57; 95%CI,1.47-1.67),女性(SIR,1.51; 95%CI(1.44–1.59))和男性(SIR,1.57; 95%CI,1.50–1.65)的2型糖尿病风险显着增加和。被诊断为IBD后的第一年,发生2型糖尿病的风险最高(SIR,4.48; 95%CI,4.16-4.83),但在诊断后20年或更长时间仍保持增加(SIR,1.26; 95%CI,1.16-1.38)。

结论:本项研究发现UC或CD患者发生2型糖尿病风险明显增加。

原始出处:

Tine Jess. Et al. Inflammatory Bowel Diseases Increase Risk of Type 2 Diabetes in a Nationwide Cohort Study. Clinical Gastroenterology Hepatology.2020.

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    2021-03-01 许安
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    2020-04-08 gwc384
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2065030, encodeId=a4c5206503079, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jan 25 09:34:11 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072949, encodeId=a3e620e2949bc, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Mar 01 10:34:11 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712372, encodeId=2db31e1237253, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Apr 24 17:34:11 CST 2020, time=2020-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427411, encodeId=8917142e41154, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Apr 08 11:34:11 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504969, encodeId=4a77150496911, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Apr 08 11:34:11 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507713, encodeId=2485150e71324, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Wed Apr 08 11:34:11 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547317, encodeId=b9fe154e31771, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Apr 08 11:34:11 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043048, encodeId=617a104304844, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Apr 06 23:34:11 CST 2020, time=2020-04-06, status=1, ipAttribution=)]
    2020-04-08 zll0628
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    2020-04-06 misszhang

    谢谢MedSci提供最新的资讯

    0

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在非糖尿病人群中,高水平的蛋白尿与听力损失有关,而轻度蛋白尿额临床影响很少有关注。最近,有研究人员进行了基于群体的代表性研究调查了在美国非糖尿病男性中,是否听力损失与轻度蛋白尿或者肾小球过滤(eGFR

JACC:接受PCI的高危糖尿病患者采用替卡格雷治疗加或不加阿司匹林疗效比较

与替卡格雷加阿司匹林相比,替卡格雷单药治疗降低临床相关出血风险而不增加缺血性事件的功效在接受PCI的糖尿病患者和非糖尿病患者中是一致的。

Nature Food: 精制淀粉和糖要为全球肥胖和糖尿病负责!

近期,Nature子刊一篇文章指出,要解决目前肥胖和2型糖尿病流行,要从食物入手,应当吃具有生物活性的食物,例如水果、坚果、种子、非淀粉类蔬菜、豆类、植物油、全谷物、酸奶和鱼,而少吃加工食物。

J Gastroenterology: 消瘦个体的胰周脂肪与2型糖尿病发生率的相关性

目前只有少数研究纵向评估了胰腺周围脂肪增多是否会增加2型糖尿病(T2D)的患病风险,但其结果并不一致。胰周脂肪与超重和肥胖密切相关,但以前的研究并未排除超重或肥胖的个体。

Nat Bio Eng:一项新技术能在体内产生胰岛素,治疗糖尿病

导言:糖尿病是一组因胰岛素绝对或相对分泌不足(或)胰岛素利用障碍引起的碳水化合物、蛋白质、脂肪代谢紊乱性疾病,以高血糖为主要标志。目前尚无根治糖尿病的方法,但通过多种治疗手段可以控制好糖尿病,主要包括

J Periodon Res:晚期糖基化终末产物增加人口腔上皮细胞脂钙蛋白2的表达

糖尿病(DM)是牙周病的危险因素,会加重牙周病的严重程度。 糖尿病并发症的主要因素之一是晚期糖基化终末产物(AGEs)在牙周组织中积累并引起炎症反应。