J Viral Hepat:丙型肝炎患者使用三环抗抑郁药物后,纤维化进程延缓和肝硬化风险降低

2018-07-27 MedSci MedSci原创

综上所述,在大量HCV阳性的退伍军人中,TCAs的使用与纤维化进程的延缓和肝硬化风险降低相关。

研究背景:最近临床前研究表明,三环抗抑郁药(TCA)具有抗纤维化作用。利用丙型肝炎病毒(HCV)感染的退伍军人队列,本研究旨在评估使用TCA对丙型肝炎病毒感染者的肝细胞癌(HCC)发展和纤维化进展的影响。

研究方法:受试者根据TCAs、选择性5-羟色胺再摄取抑制剂(SSRI)或无抗抑郁药物的使用进行分类。TCAs或选择性5-羟色胺再摄取抑制剂的使用是根据累计确定的日剂量(cDDD)来定义的,种类是相互排斥的。排除HIV共感染、乙型肝炎表面抗原(HbsAg)阳性、基线肝硬化或HCC患者。研究的主要结果是肝纤维化进展程度(采用APRI进行评估)和肝细胞癌发病率。

研究结果:该研究采用Cox比例风险回归模型来确定肝硬化(定义为> 2)以及肝细胞癌(iHCC)发生的预测因素。在12201例HCV阳性患者中,4%的患者接受TCAs, 43%的患者接受选择性5-羟色胺再吸收抑制剂,53%的患者不接受抗抑郁药物。与选择性5-羟色胺再吸收抑制剂的使用者相比,较少的TCAs使用者有药物滥用(34%和43%)和酒精滥用(32%和42%)。在调整年龄、基线评分、糖尿病高血压、酒精使用、药物滥用和HCV RNA水平等因素后,TCAs使用与降低肝硬化风险 (危险比[HR] = 0.77, 95% CI = 0.60, 0.99)和延迟肝硬化疾病发展相关,但与减少iHCC无关。

研究结论:综上所述,在大量HCV阳性的退伍军人中,TCAs的使用与纤维化进程的延缓和肝硬化风险降低相关。

原始出处:

Chen JY, Ren Y, Yan P, et al. Tricyclic antidepressant use and the risk of fibrosis progression in hepatitis C-infected persons: Results from ERCHIVES.J Viral Hepat, 2018, 25(7), 825-833.

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    2019-02-18 wetgdt
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href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Jul 29 07:34:00 CST 2018, time=2018-07-29, status=1, ipAttribution=)]
    2018-09-12 jyzxjiangqin

    丙型肝炎患者如何治疗。

    0

  5. 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href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Jul 29 07:34:00 CST 2018, time=2018-07-29, status=1, ipAttribution=)]
    2018-08-30 jyzxjiangqin

    丙型肝炎患者如何治疗?

    0

  6. 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href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sun Jul 29 07:34:00 CST 2018, time=2018-07-29, status=1, ipAttribution=)]
    2018-08-19 jyzxjiangqin

    丙型肝炎患者如何治疗。

    0

  7. 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    2018-07-29 gwc384
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