Diabetes Care:糖尿病可增加慢性心力衰竭患者致死率!

2017-05-05 MedSci MedSci原创

目前已知,糖尿病可能增加患心血管疾病(CVD)风险,同时也增加了致死风险。由于糖尿病患病率在世界范围内上升,且慢性心力衰竭(CHF)在人口老龄化中日益普遍,因此,应及时研究糖尿病1年内不良反应对CHF患者的影响。

目前已知,糖尿病可能增加患心血管疾病(CVD)风险,同时增加致死风险。由于糖尿病患病率在世界范围内上升,且慢性心力衰竭(CHF)在人口老龄化中日益普遍,因此,应及时研究糖尿病1年内不良反应对CHF患者的影响。

该研究前瞻性地评估了在欧洲心脏病学会和心力衰竭协会长期登记的9,428例CHF门诊患者的状况,其中9428例患者来自多国队列。该研究主要评估糖尿病状况是否独立影响1年全因死亡率、CVD死亡风险和心力衰竭恶化(HF)住院率。

结果显示,与无糖尿病患者相比,糖尿病患者(n = 3,440,36.5%)各项累积率分别为:1年全因死亡(9.4%vs 7.2%;调整危险比[HR] 1.28; 95%CI 1.07-1.54),CVD死亡(4.8%vs. 3.8%;调整HR 1.28; 95%CI 0.99-1.66),HF住院率(13.8%vs. 9.3%;调整HR 1.37; 95%CI 1.17-1.60)。可能影响实验结果的因素(年龄,性别,BMI,吸烟,收缩压,估计的肾小球滤过率,血红蛋白,HF病因,左心室射血分数,高血压,他汀类药物使用和先前的中风或慢性阻塞性肺疾病)全部相互独立。在基线时可获得HbA1c测量值的CHF患者(n = 2,567)中,HbA1c水平的升高与1年生存率之间存在显着和独立的关联。

该研究得出结论,糖尿病的存在显着增加了的CHF门诊1年不良临床结果的风险(多种常见危险因素相互独立)。因此,在CHF患者群体中应该考虑对糖尿病进行更有效和个性化的治疗。

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    2017-05-23 axin009
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