Science:黑色素瘤患者,肠道菌群不同,免疫治疗效果也不同!

2017-11-03 心湖,Juka 转化医学网

发表于《Science》上的一篇论文揭示了肠道菌群的作用可能并不仅仅局限于我们认知的那么小的范围。在不同的癌症之中,比如黑色素瘤,其实肠道菌群也可能有着重要的作用。

发表于《Science》上的一篇论文揭示了肠道菌群的作用可能并不仅仅局限于我们认知的那么小的范围。在不同的癌症之中,比如黑色素瘤,其实肠道菌群也可能有着重要的作用。

研究人员对进行接受PD-1免疫治疗的黑色素瘤患者进行了肠道菌群的分析。对于接受免疫治疗有作用的30名转移性黑色素瘤患者和不起作用的患者进行了肠道菌群的对比,结果发现:肠道菌群可能是导致免疫治疗效果不同的关键因素。

马里兰州贝塞斯达国家癌症研究所的免疫学家Romina Goldszmid说,尽管现在临床上通过改变抗生素使用来治疗癌症患者还为时尚早,但这项研究远远超出了之前主要依靠癌症小鼠模型的研究。同时,她强调研究人员需要更多地研究去了解这些微生物如何影响免疫系统。这个领域真正需要了解的是知道Bug在哪里,而不是去了解哪些微生物存在,哪些不存在,对此我们需要更多的信息。

原始出处:

V. Gopalakrishnan,et al.,Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients.Science.02 Nov 2017:eaan4236.

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    2018-09-30 sunylz
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    2017-11-05 jichang
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