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PLoS Pathog：研究发现KSHV导致Kaposi肉瘤发生的机制

2017-09-02 MedSci MedSci原创

延安无锡枣园中学医务室医生/ 未定级

Kaposi肉瘤（KS）常见于艾滋病患者，尤其是在撒哈拉以南的非洲地区。Kaposi肉瘤相关疱疹病毒（KSHV）是导致KS和其他癌症如原发性渗出性淋巴瘤（PEL）发生的原因。KS和PEL患者中，所有肿瘤都有潜在的KSHV基因，并可表达潜伏相关病毒蛋白和微RNA（miRNA）。潜伏KSHV导致肿瘤发生的确切分子机制目前尚未明了。近期研究发现强调了肿瘤中lncRNAs表达的重要性，且发现miRNA可下

Kaposi肉瘤（KS）常见于艾滋病患者，尤其是在撒哈拉以南的非洲地区。Kaposi肉瘤相关疱疹病毒（KSHV）是导致KS和其他癌症如原发性渗出性淋巴瘤（PEL）发生的原因。

KS和PEL患者中，所有肿瘤都有潜在的KSHV基因，并可表达潜伏相关病毒蛋白和微RNA（miRNA）。潜伏KSHV导致肿瘤发生的确切分子机制目前尚未明了。

近期研究发现强调了肿瘤中lncRNAs表达的重要性，且发现miRNA可下调lncRNAs的水平。因此，研究人员推测，KSHV编码的miRNA可下调人lncRNAs驱动肿瘤的发生。通过wt感染上皮细胞并通过miRNA删除KSHV确定lncRNA的表达谱，并确定了126个lncRNAs作为病毒miRNA的靶基因。

结果表明，KSHV可下调宿主lncRNAs，且包括MEG3、ANRIL和UCA1在内的几种lncRNAs。该研究结果还表明，KSHV 介导UCA1下调有助于增加内皮细胞的增殖和迁移。

原始出处：

Sunantha Sethuraman, Lauren Appleby Gay, et al., microRNA dependent and independent deregulation of long non-coding RNAs by an oncogenic herpesvirus. PLoS Pathog. 2017 Jul; 13(7): e1006508. Published online 2017 Jul 17. doi: 10.1371/journal.ppat.1006508.

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2018-04-11 hanhaisha2020

#研究发现#

20 0
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2017-09-16 虈亣靌

很好的研究

37 0
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2017-09-12 1e10c84am36(暂无匿称)

文章很好.值得分享

26 0
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2017-09-09 虈亣靌

好好看下.内容丰富

42 0
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2017-09-05 虈亣靌

内容丰富.值得学习

26 0
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2017-09-04 yfjms

学习了

31 0
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2017-09-03 1dd8c52fm63(暂无匿称)

学习学习.了解了解

28 0
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2017-09-02 189****7206

学习了谢谢分享

23 0

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