Blood:脑血流越低的区域,越容易发生 隐性脑梗死!

2018-08-01 MedSci MedSci原创

中心点:SCI密度图显示SCI主要位于额叶和顶叶的深层白质。脑血流越小,SCI密度越高。摘要:隐性脑梗死(SCI)与镰状细胞性贫血的认知障碍相关。SCI的风险因素包括低血红素和收缩压升高;但是,其潜在发病机制尚不明确。Andria L. Ford等人通过对儿科SCA的SCIs进行评估发现了在大脑中,SCI密度不均一;研究人员推测在脑血流最小的区域,脑梗死密度最大。研究人员对隐性脑梗死输血(SIT)

中心点:

SCI密度图显示SCI主要位于额叶和顶叶的深层白质。

脑血流越小,SCI密度越高。

摘要:

隐性脑梗死(SCI)与镰状细胞性贫血的认知障碍相关。SCI的风险因素包括低血红素和收缩压升高;但是,其潜在发病机制尚不明确。Andria L. Ford等人通过对儿科SCA的SCIs进行评估发现了在大脑中,SCI密度不均一;研究人员推测在脑血流最小的区域,脑梗死密度最大。

研究人员对隐性脑梗死输血(SIT)试验的286位患儿的脑梗死进行概述,并将其每个梗死灶都勾勒出来与大脑图集一一对应,进而建立了一个梗死密度图。为明确脑血流是否可反映梗死密度,研究人员在一个独立的儿科SCA队列中进行一间断的动脉自旋标记。

研究人员在SIT试验对比低、中、高梗死密度区域的平均血流,并以回归曲线评估随访3年的显性脑卒中临床和影像预测因素。SIT试验的梗死密度图显示额叶和顶叶深层白质的SCI密度增加。一个相对较小的区域,仅占脑容量的5.6%,但包含90%的患儿的SCIs病灶。在梗死密度最大的区域脑血流量最低(p<0.001)。起始脑梗死面积和网织红细胞计数预示了显性脑卒中的风险。在儿科SCA中,SCIs均匀的分布于脑血流最小的脑区的深层白质中。

原始出处:

Andria L. Ford, et al. Silent infarcts in sickle cell anemia occur in the borderzone region and are associated with low cerebral blood flow. Blood  2018  :blood-2018-04-841247;  doi: https://doi.org/10.1182/blood-2018-04-841247

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2042266, encodeId=1946204226622, content=<a href='/topic/show?id=754b8508329' target=_blank style='color:#2F92EE;'>#脑血流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85083, encryptionId=754b8508329, topicName=脑血流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Fri Nov 30 02:22:00 CST 2018, time=2018-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336557, encodeId=30a333655e9f, content=有没有视频版本讲解?, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7ceOChkqicg6SzjqymjoEtLx55A9HNpmV1quNDdicpmTPZp1WXCq35u64iaCjRhibmrEPN5JHdvOZt9Ajj4MxzLbJ9/0, createdBy=ddf3111026, createdName=jawel, createdTime=Sun Aug 05 09:01:45 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465116, encodeId=a9c314651163b, content=<a href='/topic/show?id=2dea8489010' target=_blank style='color:#2F92EE;'>#脑梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84890, encryptionId=2dea8489010, topicName=脑梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccf56689148, createdName=karmond, createdTime=Fri Aug 03 04:22:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335721, encodeId=324f335e2111, content=受教了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eZGicuFRFFTALbdQweicbJ27mkoA7FpoE8ibquTudxTCRKJVDZU43Dwlh08ULiauSCZVUJK6dRMnvySia3ESurkIRsQ/132, createdBy=77732410194, createdName=Dr.流连忘返, createdTime=Thu Aug 02 08:35:17 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335672, encodeId=0e3c3356e225, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Thu Aug 02 06:52:49 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335541, encodeId=2a8f33554165, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Wed Aug 01 13:33:12 CST 2018, time=2018-08-01, status=1, ipAttribution=)]
    2018-08-05 jawel

    有没有视频版本讲解?

    0

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    2018-08-03 karmond
  4. [GetPortalCommentsPageByObjectIdResponse(id=2042266, encodeId=1946204226622, content=<a href='/topic/show?id=754b8508329' target=_blank style='color:#2F92EE;'>#脑血流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85083, encryptionId=754b8508329, topicName=脑血流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Fri Nov 30 02:22:00 CST 2018, time=2018-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336557, encodeId=30a333655e9f, content=有没有视频版本讲解?, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7ceOChkqicg6SzjqymjoEtLx55A9HNpmV1quNDdicpmTPZp1WXCq35u64iaCjRhibmrEPN5JHdvOZt9Ajj4MxzLbJ9/0, createdBy=ddf3111026, createdName=jawel, createdTime=Sun Aug 05 09:01:45 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465116, encodeId=a9c314651163b, content=<a href='/topic/show?id=2dea8489010' target=_blank style='color:#2F92EE;'>#脑梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84890, encryptionId=2dea8489010, topicName=脑梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccf56689148, createdName=karmond, createdTime=Fri Aug 03 04:22:00 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335721, encodeId=324f335e2111, content=受教了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eZGicuFRFFTALbdQweicbJ27mkoA7FpoE8ibquTudxTCRKJVDZU43Dwlh08ULiauSCZVUJK6dRMnvySia3ESurkIRsQ/132, createdBy=77732410194, createdName=Dr.流连忘返, createdTime=Thu Aug 02 08:35:17 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335672, encodeId=0e3c3356e225, content=学习学习很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Thu Aug 02 06:52:49 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335541, encodeId=2a8f33554165, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Wed Aug 01 13:33:12 CST 2018, time=2018-08-01, status=1, ipAttribution=)]
    2018-08-02 Dr.流连忘返

    受教了!

    0

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    2018-08-02 易水河

    学习学习很好

    0

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    2018-08-01 jihuaijun1112

    学习学习学习

    0