Am J Transl Res:研究鉴定骨质疏松症患者骨髓中差异表达的microRNA

2019-06-21 不详 网络

本研究旨在鉴定与人类绝经后骨质疏松症(OP)相关的特定microRNA(miRNA)。结果显示,共有67个保守的miRNA,包括明显上调的50个miRNA和17个明显下调的miRNA,表明OP组和对照组之间存在差异表达。预测了180个发夹结构和199个潜在的新型miRNA候选物,其长度为18至25nt,这将极大地富集人miRBase。4种miRNA(miR-518b,miR-582-3p,miR-

本研究旨在鉴定与人类绝经后骨质疏松症(OP)相关的特定microRNA(miRNA)。

结果显示,共有67个保守的miRNA,包括明显上调的50个miRNA和17个明显下调的miRNA,表明OP组和对照组之间存在差异表达。预测了180个发夹结构和199个潜在的新型miRNA候选物,其长度为18至25nt,这将极大地富集人miRBase。4种miRNA(miR-518b,miR-582-3p,miR-148a-3p和miRNA-223-3p)表达上调,4种(miR-7d-5p,miR-210-3p,miR-324-5p和miR -654-3p)的表达显示下调。这些miRNA的靶基因参与骨发育,骨髓中的细胞增殖,成骨细胞发育,成骨细胞分化的负调节和破骨细胞发育的负调节,以及几种成骨相关途径。选择Canonical Wnt信号通路进行验证和功能分析。Wnt1,FZD10,LRP5,DVL2和LEF1的表达显著下调,而SFRP1,DKK1和CHD8的表达显著上调。

总之,该研究结果表明,这些基因在OP中起重要作用,这提高了我们对OP发病机制的理解。

原始出处:

Gu H, Wu L, et al., Identification of differentially expressed microRNAs in the bone marrow of osteoporosis patients. Am J Transl Res. 2019 May 15;11(5):2940-2954. eCollection 2019.

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    2020-05-12 xjy02
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    2020-05-01 bsmagic9140
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1649202, encodeId=910b164920217, content=<a href='/topic/show?id=591d48262d1' target=_blank style='color:#2F92EE;'>#差异表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48262, encryptionId=591d48262d1, topicName=差异表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7bc23772344, createdName=mfx807, createdTime=Fri May 01 17:29:00 CST 2020, time=2020-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857807, encodeId=3674185e80752, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Oct 31 09:29:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084530, encodeId=04fe20845306e, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue May 12 02:29:00 CST 2020, time=2020-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657184, encodeId=7ab0165e184d5, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Fri May 01 16:29:00 CST 2020, time=2020-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067444, encodeId=52c2206e44475, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Feb 10 09:29:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435769, encodeId=a5021435e6912, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Jun 23 14:29:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592580, encodeId=5e071592580cc, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Jun 23 14:29:00 CST 2019, time=2019-06-23, status=1, ipAttribution=)]
    2019-06-23 zhouqu_8
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    2019-06-23 Eleven17