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Int J Mol Sci：携带HGF基因的重组腺病毒对人骨髓间充质干细胞增殖和成骨分化的作用

2018-03-14 MedSci MedSci原创

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目前仍缺乏对股骨头缺血性坏死（ANFH）的有效治疗方法。骨髓间充质干细胞（BMSCs）过继性细胞治疗联合核心减压术是一种很有前景的治疗方式，高度依赖于BMSCs的细胞活性。肝细胞生长因子（HGF）是BMSCs的生存因子，但其基本机制尚未完全阐明。在本研究中，研究人员系统探究了携带HGF基因的重组腺病毒（rAd-HGF）对人BMSCs增殖和成骨分化的感染复数（MOI）的影响。感染rAd-HGF产生分

目前仍缺乏对股骨头缺血性坏死（ANFH）的有效治疗方法。骨髓间充质干细胞（BMSCs）过继性细胞治疗联合核心减压术是一种很有前景的治疗方式，高度依赖于BMSCs的细胞活性。肝细胞生长因子（HGF）是BMSCs的生存因子，但其基本机制尚未完全阐明。

在本研究中，研究人员系统探究了携带HGF基因的重组腺病毒（rAd-HGF）对人BMSCs增殖和成骨分化的感染复数（MOI）的影响。感染rAd-HGF产生分泌型HGF并以MOI依赖性方式促进hBMSCs增殖，而成骨作用也增强，如钙结节形成增强，其中在MOI = 250时达到最强效果。阻断c-MET或其下游信号通路WNT，ERK1/2和PI3K/AKT导致不同的结果。具体而言，WNT途径的阻断明显促进成骨分化，当与rAd-HGF联合应用时也显示出增强效应。

宗旨，该研究结果证实了rAd-HGF的优化MOI的促成骨作用，而WNT通路的抑制或PI3K/AKT通路的激活可作为促进rAd-HGF-修饰的hBMSCs治疗ANFH中的成骨分化的促进剂。

原始出处：

Wen Q, Zhang S, et al., The Multiplicity of Infection-Dependent Effects of Recombinant Adenovirus Carrying HGF Gene on the Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells. Int J Mol Sci. 2018 Mar 5;19(3). pii: E734. doi: 10.3390/ijms19030734.

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    2019-02-14 ms7514935887898259

    #重组腺病毒#

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    2018-05-26 h.y200607_23674418

    #间充质干细#

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    2019-01-16 ying_wu

    #骨髓间充质干细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1687222, encodeId=5993168e22228, content=<a href='/topic/show?id=6a5b9604106' target=_blank style='color:#2F92EE;'>#重组腺病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96041, encryptionId=6a5b9604106, topicName=重组腺病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ddd28353190, createdName=ms7514935887898259, createdTime=Thu Feb 14 21:28:00 CST 2019, time=2019-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815299, encodeId=9f39181529991, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat May 26 02:28:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705452, encodeId=2bfb1e0545238, content=<a href='/topic/show?id=31f9102015b3' target=_blank style='color:#2F92EE;'>#骨髓间充质干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102015, encryptionId=31f9102015b3, topicName=骨髓间充质干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723a30986413, createdName=ying_wu, createdTime=Wed Jan 16 18:28:00 CST 2019, time=2019-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821298, encodeId=2d871821298f6, content=<a href='/topic/show?id=428a101612e7' target=_blank style='color:#2F92EE;'>#骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101612, encryptionId=428a101612e7, topicName=骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Aug 16 03:28:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656425, encodeId=562a16564250b, content=<a href='/topic/show?id=fe718e8939' target=_blank style='color:#2F92EE;'>#HGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8789, encryptionId=fe718e8939, topicName=HGF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=442324829126, createdName=zhaozuguo, createdTime=Fri Jul 20 08:28:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337444, encodeId=0210133e44486, content=<a href='/topic/show?id=863f5409610' target=_blank style='color:#2F92EE;'>#成骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54096, encryptionId=863f5409610, topicName=成骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Fri Mar 16 05:28:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351673, encodeId=4b0d13516e334, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 16 05:28:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540915, encodeId=d53315409157d, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Fri Mar 16 05:28:00 CST 2018, time=2018-03-16, status=1, ipAttribution=)]
    2018-08-16 HinsMax

    #骨分化#

    0

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    2018-07-20 zhaozuguo

    #HGF#

    0

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    2018-03-16 ms5880526374914242

    #成骨分化#

    0

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    2018-03-16 zhaojie88

    #成骨#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1687222, encodeId=5993168e22228, content=<a href='/topic/show?id=6a5b9604106' target=_blank style='color:#2F92EE;'>#重组腺病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96041, encryptionId=6a5b9604106, topicName=重组腺病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ddd28353190, createdName=ms7514935887898259, createdTime=Thu Feb 14 21:28:00 CST 2019, time=2019-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815299, encodeId=9f39181529991, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat May 26 02:28:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705452, encodeId=2bfb1e0545238, content=<a href='/topic/show?id=31f9102015b3' target=_blank style='color:#2F92EE;'>#骨髓间充质干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102015, encryptionId=31f9102015b3, topicName=骨髓间充质干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723a30986413, createdName=ying_wu, createdTime=Wed Jan 16 18:28:00 CST 2019, time=2019-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821298, encodeId=2d871821298f6, content=<a href='/topic/show?id=428a101612e7' target=_blank style='color:#2F92EE;'>#骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101612, encryptionId=428a101612e7, topicName=骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Thu Aug 16 03:28:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656425, encodeId=562a16564250b, content=<a href='/topic/show?id=fe718e8939' target=_blank style='color:#2F92EE;'>#HGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8789, encryptionId=fe718e8939, topicName=HGF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=442324829126, createdName=zhaozuguo, createdTime=Fri Jul 20 08:28:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337444, encodeId=0210133e44486, content=<a href='/topic/show?id=863f5409610' target=_blank style='color:#2F92EE;'>#成骨分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54096, encryptionId=863f5409610, topicName=成骨分化)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Fri Mar 16 05:28:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351673, encodeId=4b0d13516e334, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 16 05:28:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540915, encodeId=d53315409157d, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Fri Mar 16 05:28:00 CST 2018, time=2018-03-16, status=1, ipAttribution=)]
    2018-03-16 晓辰

    #细胞增殖#

    0