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J Periodontol: 哈金森-吉尔福德早衰综合征患儿牙龈退缩部位的微生物群

2018-07-21 MedSci MedSci原创

HGPS牙龈退缩微生物
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哈金森 - 吉尔福德早衰综合征（HGPS）是一种罕见的早衰症，伴有明显的口腔和牙齿异常。临床症状包括加速衰老的各种特征，例如脱发，皮下脂肪减少，骨骼异常和早发心血管疾病。此外，HGPS的患儿还有全口牙龈退缩症状。而与该综合征相关的牙周表现与口腔菌群变化的关系尚不清楚。本研究旨在确定HGPS患儿牙龈退缩部位的微生物组成。

哈金森 - 吉尔福德早衰综合征（HGPS）是一种罕见的早衰症，伴有明显的口腔和牙齿异常。临床症状包括加速衰老的各种特征，例如脱发，皮下脂肪减少，骨骼异常和早发心血管疾病。此外，HGPS的患儿还有全口牙龈退缩症状。而与该综合征相关的牙周表现与口腔菌群变化的关系尚不清楚。本研究旨在确定HGPS患儿牙龈退缩部位的微生物组成。

9名患有HGPS的儿童参加了这项研究。从牙龈退缩的部位收集牙菌斑样本。使用人口腔微生物鉴定微阵列（HOMIM）分析DNA样本。将HGPS儿童的微生物谱与健康个体（n = 9）和牙周病患者（n = 9）的样本进行比较。

结果发现，HGPS与牙周健康样本的微生物组成相比，两种菌群有显着差异； Porphyromonas catoniae和Prevotella oulora存在于HGPS样本中，而健康组没有。 HGPS和牙周病组之间有20个细菌类群有统计学差异。

在HGPS儿童中，牙龈退缩的部位不存在典型的牙周病原体。 HGPS中牙龈退缩和附着丧失部位的微生物组成通常比牙周健康更类似于牙周病。除了典型的牙周病原体之外，还有其他菌种可能参与了牙龈退缩。

原始出处：

Seyed Hossein Bassir， et al. Microbiome at sites of gingival recession in children with Hutchinson-Gilford progeria syndrome. Journal of Periodontology. 2018 June. doi： 10.1002/JPER.17-0351

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    2019-03-20 feather89

    #PE#

    0

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    2019-03-28 wjcjjian

    #微生物#

    0

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    2018-07-23 zhu_jun9837

    #微生物群#

    0

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    2018-07-23 zhouqu_8

    #综合征#

    0

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    2018-07-23 木头人515

    #牙龈退缩#

    0

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    2018-07-22 飛歌

    厉害了我的妹

    0

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    2018-07-21 惠映实验室

    学习了，谢谢分享。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1727450, encodeId=fb201e274501c, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Mar 20 12:20:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824944, encodeId=718718249441d, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Mar 28 23:20:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367752, encodeId=62c5136e75207, content=<a href='/topic/show?id=2cee50e22c6' target=_blank style='color:#2F92EE;'>#微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50722, encryptionId=2cee50e22c6, topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Mon Jul 23 08:20:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431275, encodeId=f55d14312e579, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jul 23 08:20:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457132, encodeId=5ce2145e132bf, content=<a href='/topic/show?id=e7dc6e74623' target=_blank style='color:#2F92EE;'>#牙龈退缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67746, encryptionId=e7dc6e74623, topicName=牙龈退缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78355846342, createdName=木头人515, createdTime=Mon Jul 23 08:20:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333239, encodeId=b04e333239a1, content=厉害了我的妹, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jul 22 00:36:06 CST 2018, time=2018-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333212, encodeId=3171333212a5, content=学习了，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Jul 21 20:53:04 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333199, encodeId=43ac33319964, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat Jul 21 19:30:28 CST 2018, time=2018-07-21, status=1, ipAttribution=)]
    2018-07-21 天地飞扬

    了解一下，谢谢分享！

    0